SSA Attachment 2 Council Minutes

NATIONAL HEART, LUNG, AND BLOOD ADVISORY COUNCIL - NHLBI, NIH
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NATIONAL HEART, LUNG, AND BLOOD ADVISORY COUNCIL
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NATIONAL HEART, LUNG, AND BLOOD ADVISORY COUNCIL

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October 22, 2013
The 253rd meeting of the National Heart, Lung, and Blood Advisory Council (NHLBAC) was convened at 12:30 p.m. on Tuesday,
October 22, 2013, in Conference Room 10, C Wing, Building 31, National Institutes of Health (NIH), Bethesda, Maryland. The
meeting was open to the public until 1:37 p.m. The closed session began at 1:43 p.m. and adjourned at 2:46 p.m. Dr. Gary H.
Gibbons, Director of the National Heart, Lung, and Blood Institute (NHLBI), presided as Chair.
Council members attending via teleconference:
Mr. Jonathan R. Alger
Dr. Ivor J. Benjamin
Dr. George Q. Daley
Dr. Pamela S. Douglas
Dr. Jonathan A. Epstein
Dr. Lanetta B. Jordan
Dr. Ron G. King
Dr. Talmadge E. King
Dr. Barbara A. Konkle
Dr. Naomi L.C. Luban
Dr. Polly E. Parsons
Dr. Bruce M. Psaty
Dr. Veronique Lee Roger
Dr. Leslee J. Shaw
Dr. Anna Maria Siega-Riz
Dr. Gilbert C. White
Dr. Jeffrey A. Whitsett
Council members absent:
Dr. Coletta C. Barrett
Dr. Robert L. Jesse (ex officio)
Members of the public present:
Ms. Virginia Mechan, Northwestern University
Ms. Karen Mowrer, Lewis Burke Associates
Ms. Nancy Moy, SRI International
Ms. Emily Smith, RTI International
Mr. Victor Zulkosky, Social and Scientific Systems
CSR Employees present:
Dr. Lawrence Boerboom
Dr. Kathy Malinda
Dr. Ai-Ping Zou
NHLBI employees present:
Some NHLBI staff were in attendance or were able to listen to the meeting via teleconference.
I. CALL TO ORDER
Dr. Gary H. Gibbons, Director of the National Heart, Lung, and Blood Institute (NHLBI), called the 253rd meeting of the National
Heart, Lung, and Blood Advisory Council (NHLBAC) to order. All Council members attended via teleconference. Dr. Gibbons
updated members on NHLBI actions during the 16-day Government shutdown and startup activities. He also thanked staff for

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NATIONAL HEART, LUNG, AND BLOOD ADVISORY COUNCIL - NHLBI, NIH
their role in ensuring that the meeting occurred three days after the shutdown ended. He talked about the current Continuing
Resolution that is in place until January 15, 2014. The NHLBI will use a 90 percent-level ?hold back? until the budget picture is
more settled and it will use similar governing principles of the past year ? shared sacrifice, preserve the number of R01s, and
protect Early Stage Investigators. He mentioned upcoming fiscal challenges and the potential of more sequester cuts, but
expressed an optimistic goal of a payline at the 10-12 percentile. Because this was an abbreviated meeting due to the shutdown,
Dr. Gibbons highlighted the February 2014 draft agenda that will include an update on BEECom, the role of Council in the
Institute?s Strategic Visioning and Planning, a presentation by a Division of Intramural Research investigator, and a discussion of
the Enhancing Reproducibility Initiative.
II. ADMINISTRATIVE ANNOUNCEMENTS
Dr. Stephen C. Mockrin, Director of the Division of Extramural Research Activities, updated members on the status of operations
following the Government shutdown (October 1-16). He stressed that things continue to be very fluid. October application receipt
dates have all been rescheduled to November so applicants have access to NIH staff and electronic systems. Applicants who have
already made their submissions have the opportunity to replace the original application with a ?refreshed? one, without it being
counted as a resubmission. NHLBI canceled 11 peer review meetings during the shutdown. All will be held, as planned or
rescheduled in time to go to February Council. Overall, the shutdown forced the Center for Scientific Review to cancel more than
200 peer review meetings, affecting more than 11,000 applications. Those will be rescheduled for review in February and March,
and will be reassigned to the May/June Council round. Despite this announced timeline, CSR is looking into completing reviews by
mid-December so they can be assigned to the January/February round of Council meetings. The NIH will adjust the Early Stage
Investigator status for applicants whose status changed during the shutdown. There is no information about timelines for the NIH
Pathway to Independence Award Program (K99/R00). Adjustments to eligibility status will be made, as appropriate.
III. REPORT OF THE BOARD OF EXTERNAL EXPERTS AND INITIATIVE CONCEPTS
NHLBI staff presented eight initiatives and renewals, which were reviewed in September by the Board of External Experts (BEE).
Initiative development at the NHLBI is a two-cycle process. First, staff within each extramural division develops ideas and
potential initiatives, which they present to the trans-NHLBI Idea Forum. Sufficiently developed initiatives are subsequently
considered by the BEE, which ranks them and provides accompanying advice. The Council was mostly supportive of the initiatives
presented, but made a number of specific recommendations for consideration prior to their release. The Director, NHLBI, will
consider the recommendations of the BEE and the Council and other budgetary and programmatic issues in determining which of
the proposed initiatives, if any, to implement.
INITIATIVES: SBIR/STTR
Initiative: Cardiovascular Development Consortium (U01)
Purpose: To create and share with the larger investigative community comprehensive knowledge of developmental cardiovascular
networks, and to identify the series of mechanistic events that give rise to complex anatomic abnormalities in individuals with
congenital heart disease (CHD).
Initiative: Pediatric Cardiac Genomics Consortium (U01)
Purpose: To improve the mechanistic understanding of how a genetic variant is temporally and spatially translated into an
anatomic abnormality; To understand how genetic variants may impact key clinical outcomes, such as arrhythmias, impaired
neurodevelopment, pulmonary vascular disease, and thrombotic complications; To increase the cadre of researchers and
resources to sustain multidisciplinary, integrated research in congenital heart disease (CHD) pathogenesis.
Initiative: Women's Health Initiative (WHI) Renewal (N01)
Purpose: To 1) expand knowledge about the determinants of cardiovascular disease in older women (and conversely
determinants of successful aging with absence of cardiovascular disease); 2) expand the study as a scientific resource for the
research community; 3) mentor young investigators; and 4) facilitate a new generation of large simple prevention trials.
Initiative: Chronological Animal Models for Diseases of Heart, Lung, Blood, or Sleep (Type 3, Competitive Revision) (R01)
Purpose: To encourage researchers to interrogate the variable time in the pathogenesis of chronic diseases by using rodents or
other animals of disease-critical age in a targeted set of experiments within the general scope of previously awarded NHLBIfunded R01s. It would allow researchers to interrogate a system that may more closely correspond to the human chronic diseases
within the frame of their ongoing research.
Initiative: : Enriching the Hematology Research Workforce through Short-term Training in Emerging Science (R25)
Purpose: To maximize the scientific value of established research resources by providing them with a mentoring and training
component that offers junior investigators the opportunities to acquire advanced targeted scientific tools with which to establish
or enhance a blood research career.
Initiative: Sickle Cell Disease in Sub-Saharan Africa (U01)
Purpose:To establish a sustainable sickle cell disease (SCD) investigative network in sub-Saharan Africa. Such capacity building is
intended to advance future SCD related epidemiologic, clinical, and implementation research.
CLOSED PORTION
This portion of the meeting was closed to the public in accordance with the determination that it concerned matters exempt from
mandatory disclosure under Sections 552b(c)(4) and 552b(c)(6), Title 5, U.S. Code and Section 10(d) of the Federal Advisory
Committee Act, as amended (5 U.S.C. appendix 2).
IV. REVIEW OF INTRAMURAL RESEARCH

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NATIONAL HEART, LUNG, AND BLOOD ADVISORY COUNCIL - NHLBI, NIH
Reports prepared by the Board of Scientific Counselors (BSC), NHLBI, on the NHLBI intramural laboratories reviewed during FY
2013 were presented to the Council by Dr. Robert Balaban, Director, Division of Intramural Research, NHLBI, and Dr. Douglas
Wallace (BSC Chair), Children?s Hospital of Philadelphia.
V. REVIEW OF APPLICATIONS
The session included a discussion of procedures and policies regarding voting and confidentiality of application materials,
committee discussions and recommendations. Members absented themselves from the meeting during discussion of and voting
on applications from their own institutions, or other applications in which there was a potential conflict of interest, real or
apparent. Members were asked to sign a statement to this effect. The Council considered and approved 1,004 applications
requesting $1,405,451,027 in total direct costs.
ADJOURNMENT
The meeting was adjourned at 2:46 p.m.

Last Updated July 2014

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