Attachment A.1.2: RFA-RM-13-019

2/19/2014

RFA-RM-13-019: NIH Directors Biomedical Research Workforce Innovation Award: Broadening Experiences in Scientific Training (BEST) (DP7)

Attachment A.1.2: RFA-RM-13-019

Department of Health and Human Services

_{Part 1. Overview Information}

Participating Organization(s)	National Ins titute s of Health (NIH) Office o f Str ategi c Coo rdina tion (Com m on Fu nd)
Components of Participating Organizations	Thi s Fun ding Oppor tunity Ann ounce m ent (FOA) is d evelo ped a s a Com m on Fund i nitia tive (http ://co m m onfund.n ih.go v/) throug h the NIH Office o f the NIH Direc tor, Offic e of Strategic Coord inati on (http://dpcps i.nih .gov/os c/) . Th e FOA will be a dm ini s tere d by the N ation al Ins titute of Denta l and Cran iofac ial R es ear ch (h ttp://www.nidcr .nih.gov/) on behal f of the N IH.
Funding Opportunity Title	NIH Dire ctor’s Bio medic al Re searc h Workforc e Innovation Award: Broad ening Expe rienc es in Scientif ic Training (BE ST) (DP7)
Activity Code	DP7 Dire ctor’ s Bio m edic al Re s earc h Wor kforc e Inn ovati on Aw ard Pro gram
Announcement Type	Rei s s ue of RFA-RM- 12-02 2
Related Notices	Jan uary 30, 2 014 - See Notic e NOT-RM-1 4-006 . Notice o f Inform ational Webi nar.
Funding Opportunity Announcement (FOA) Number	RFA -RM-1 3-019
Companion Funding Opportunity	Non e
Number of Applications	See Section III. 3 . Add ition al In form a tion on El igibi lity.
Catalog of Federal Domestic Assistance (CFDA) Number(s)	93.310
Funding Opportunity Purpose	The purp os e o f thi s FOA is to s ee k out, ide ntify and s uppo rt bo ld an d inn ovati ve ap proac hes d es ign ed to broa den g radua te an d pos tdoctoral tra ining , s uc h tha t tra ining prog ram s refle ct th e ran ge of care er op tions tha t Ph.D. gr aduate s tu dents and pos td octor al (r egard les s of fu nding s ou rce) purs u e and that are requi red for a robus t bio m edic al, b ehavi oral, s oc ial a nd cl inica l res earch ente rpris e. Co llabo ratio ns wi th no n- aca dem ic partners are e ncour aged to en s ure that exper ts fr om a broad s pe ctrum of r es ear ch-in tens i ve an d res earch -rela ted c areer s con tribu te to cours ework , rotation s , in terns hips or other form s of expos ur e. Th is pro gram will es tab lis h a new para digm for g radua te an d pos tdoctoral tra ining ; awa rdee ins ti tutio ns wi ll wo rk to gethe r to defin e nee ds an d s ha re be s t pr actic es .

Key Dates

Posted Date	Jan uary 17, 2 014
Open Date (Earliest Submission Date)	Feb ruary 28, 2014
Letter of Intent Due Date(s)	Feb ruary 28, 2014
Application Due Date(s)	Mar ch 31 , 201 4, by 5:00 PM l ocal tim e of ap plica nt or ganization . App lican ts ar e enc ourag ed to appl y ear ly to allo w ade quate tim e to m ake any corr ectio ns to erro rs fo und i n the appl icati on du ring the s ubm is s ion pro ces s by th e due date .
AIDS Application Due Date(s)	Not Appl icabl e
Scientific Merit Review	Jun e/Jul y 201 4
Advisory Council Review	Aug us t 2 014
Earliest Start Date	Sep tem be r 201 4
Expiration Date	Apr il 1, 2014
Due Dates for E.O. 123 72	Not Appl icabl e

Required Application Instructions

It is cr itica l tha t app lican ts fo llow the i ns tru ction s in the S F424 (R&R) Appl icati on Gu ide e xcept wher e ins tructed to do o therw is e ( in th is FOA or in a Notic e fro m the NIH Guide for Grants and Contracts ). Con form a nce to all requ irem e nts ( both in th e App lication Guide and the FOA) is requ ired and s trictly enforced . App lican ts m u s t re ad an d fol low a ll ap plica tion ins tr uctio ns in the Appli catio n Gui de as well as a ny pro gram - s peci fic i ns tru ction s noted in Section IV. Wh en th e pro gram - s peci fic i ns tru ction s deviate from thos e in the Applic ation Guid e, fo llow the p rogra m -s pe cific ins tructi ons .

_{Applicat ions that do not com ply w ith t hese instr uctions will not be revie wed}

Apply for Grant Electronically

A c om patible vers i on of Adob e Rea der i s req uired for downl oad. For As s is tance downl oadin g thi s or any Gra nts .g ov ap plica tion packa ge, p leas e contact Grants .gov Cus to m er S uppor t at http://w ww07.grants .gov/contactus /contactus .js p.

Table of Contents

Par t 1. Overview Inform ation

Par t 2. Full Text of th e Ann ounce m ent Sec tion I. Fu nding Oppo rtuni ty De s crip tion Sec tion II. Award Infor m atio n Sec tion III. Eligi bility Inform ation Sec tion IV. Applic ation and Subm i s s ion Info rm ati on Sec tion V. Ap plica tion Revie w Inform ation Sec tion VI. Award Adm in is tra tion Infor m atio n Sec tion VII. Agenc y Con tacts Sec tion VIII. Othe r Inform ation

Part 2. Full Text of Announcement

Section I. Funding Opportunity Description

Thi s ini tiati ve is fund ed th rough the NIH C om m on Fund , whi ch s u pports cro s s cutting progr am s that a re exp ected to h ave e xceptional ly hi gh im pact. All Com m o n Fun d ini tiati ves i nvite appl icants to devel op bo ld, inn ovati ve, a nd often-r is ky appro aches to a ddres s pro blem s that m ay s eem intra ctabl e or to s e ize n ew opp ortun ities that offe r the pote ntial for rapid prog res s .

Background

Thi s ini tiati ve is deve loped in r es pon s e to reco m m end ation s pro vided by the Ad vis or y Com m itte e to the Dir ector (ACD ), NIH. Th e com m itte e s tu died the c urren t s ta te of the biom e dical res e arch workforce, and NIH ’s s u pport of traini ng fo r thi s wor kforc e (http://acd.o d.nih .gov/Biom e dical _res e arch_ wgrep ort.p df). The ACD repo rt co nfirm s tha t although the vas t m ajor ity o f peo ple h oldin g bio m edic al Ph Ds ar e pro ducti vely em p loyed , the prop ortio n of PhDs that m ove into tenur e-tra ck or tenu red faculty pos ition s rep res en ts a m in ority of the tr ainee outc om es . An i ncrea s ing propo rtion of g radua te s tudents and pos tdocto ral fellow s con duct res ea rch i n non -acad em ic venue s s uc h as gover nm ent or p rivate s ec tor, or ar e in areas s uch as s ci ence polic y. De s pite the broad rang e of caree r options avail able to U.S.-tr ained PhD biom e dical

s ci entis ts , g radua te pr ogram s and pos tdocto ral traini ng fo cus a lm os t excl us ive ly on prep aring indi vidua ls fo r car eers as ac adem i c res earch ers . The ACD co m m ittee re com m e nded that NIH-s uppor ted g radua te pro gram s and pos td octor al tr ainin g be broad ened to re flect the actua l car eer o utcom es of toda y’s P hD gra duate s and pos tdocto ral s cientis ts . For the p urpos es of this FOA, a “r es ear ch-in tens i ve” c areer is d efine d as an oc cupation i n whi ch re s earc h is perfo rm ed in an y ven ue, i nclud ing i ndus try, a cadem ia, g overn m ent or entrepre neuri al pu rs uits . “R es ear ch-re lated ” car eers are d efine d as occup ation s tha t dir ectly s upp ort the bio m edic al re s earc h enterpri s e. P leas e s ee http://bio m edic alres earch workforce.nih.g ov/ w hich refle cts the cur rent s tate of N IH’s effor ts to ward this goal.

Program Objectives

In cons i deration o f the s e re com m e ndati ons , this progr am in vites appl icati ons that p ropos e the

es tablis hm ent, im p lem en tatio n, an d as s es s m e nt of inno vative app roach es an d activiti es to broa den a nd com plem e nt tr aditi onal res ea rch traini ng in biom edica l, be havio ral, s ocia l and clin ical (refe rred to as

‘bi om edi cal’) s cie nces . Thes e awa rds , als o calle d the Broa denin g Exp erien ces i n Sci entific Tr ainin g (BEST) awa rds , will provi de s u pport for ins ti tutio ns to deve lop n ovel ideas in traini ng an d wor kforc e developm ent. The goal of this p rogra m is to be tter prepa re pr edoctoral s tude nts a nd po s tdoc toral s cie ntis ts for the bread th of caree rs in the biom e dical res e arch workforce and to es tablis h a n etwor k to devel op, s hare, eval uate, and dis s em in ate b es t p racti ces w ithin the train ing c om m un ity.

The anno uncem ent s eeks appli catio ns fr om in s titu tions with es ta blis h ed pr edoctoral progr am s . If an app lican t ins titution a ls o trains a s i gnifi cant num be r of pos td octor al s c ienti s ts , the p ropos ed pr ogram des igned in r es pon s e to this FOA m us t als o inclu de a plan to ad dres s the needs of the po s tdoc toral

s ci entis ts . We invite b old a nd in novative a pplic ation s tha t leverage exis ting ins ti tutio nal r es our ces to bro aden and enri ch tr ainin g exp erien ces s o tha t par ticip ants are e xpos e d to m ulti ple r es ear ch-in tens i ve an d

res earch -rela ted c areer path s ear ly in thei r tra ining . Pro gram s s hou ld id entify var ious caree r paths an d develop m eani ngful oppo rtuni ties targe ting thos e path ways . Participa nts ( both gradu ate s tuden ts an d pos tdoctoral fello ws ) a re expecte d to have the o pportunity to s elect from am on g the s e pr epara tory

exp erien ces . The p rogra m is not m eant to tr ain them fully for n ew ca reer optio ns , b ut s h ould prepa re th em for the next s teps in their caree r developm ent.

App lications res po ns ive to this FOA s h ould provi de op portu nitie s to acqui re a worki ng kn owled ge of the s ki lls n eces s ary for a wide range of s ucces s ful caree rs in the biom e dical res e arch workforce. The goal of thi s FOA is to bro aden both docto ral a nd po s tdoc toral trad ition al tr ainin g exp erien ces s uch that the par ticip ants are b etter prep ared for c areer s in a var iety of ve nues , incl uding indu s try, gove rnm en t, ac adem i a, or entre prene urial ente rpris es . While it is expe cted that parti cipan ts in tendi ng to ente r aca dem ic res e arch car eers will benefit fr om br oader expe rienc e, pr ogram s des igned excl us ive ly to targ et ac adem i c res earch

car eers will be co ns ide red n on-re s pons ive. For i ndivi duals s eek ing c areer s in res ea rch-r elate d are as , s uch as s cien ce po licy, tech nolog y tra ns fer , m an agem e nt or othe r are as re quiri ng th e res earch doctorate in bio m edic al s c ience , NIH s eek s app lications to pr ovide grad uate s tude nts a nd po s tdoc toral fell ows m ea ningful tr ainin g exp erien ces s o tha t the y are better pr epare d to enter thos e occ upati ons a s wel l as for res earch -inte ns ive care ers i n the private s ector .

App lican ts ar e als o enc ourag ed to incl ude the de s ign of po s itive and attr active exi t pathways for thos e ind ividu als i ntend ing c areer s tha t do not r equir e a r es ear ch do ctora te. More b roadl y, NIH s ee ks in novative bus ines s and acade m ic m odels of h ow gr aduate pro gram s in b iom ed ical res ea rch s cienc es de fine the m s elves an d the ir pu rpos e , how they recr uit, adm it, s up port, s tee r and m entor s tudents to prepa re th em app ropri ately for chos e n bio m edic al re s earc h-intens ive or res ea rch-r elate d car eers . It i s not expe cted that app lican ts m u s t pr ovide expe rienc es in all res ea rch-i ntens ive o r res earch -rela ted o utcom es , b ut pr ogram s s ho uld target as pe cts o f tra ining that will enha nce their exis ting p rogra m s an d add to a m ore well -roun ded app roach .

App lican ts ar e enc ourag ed to form partners h ips w ith o rgani zatio ns th at em ploy s cien tis ts enga ged i n the car eers for w hich the traini ng experie nces are d irected (p rivate s ec tor, publi s hing , governm e nt, e tc.). Partner org aniza tions m ay provi de op portu nitie s for inte rns hi ps , their s taff m ay parti cipate in the d evelo pm ent and im p lem en tatio n of novel curr icula , and /or they m ay co ntrib ute i n oth er wa ys to the s ucce s s of the progr am .

Ins titutions that are c urren tly e xplor ing n ovel appro aches are encou raged to a pply but m us t c arefu lly e xplai n how s upp ort from this a ward would s ubs tanti ally com pl em ent and/or ad d new dim e ns ion s to their exis ting pro gram s . App lications that reque s t ad ditio nal s uppor t onl y to m aintain a n exi s ting prog ram w ill b e dee m ed non -res p ons ive. Exam ple s of innovative appr oache s inc lude but a re no t lim ited to: e xchan ge ar range m ents with oth er s c hools and progr am s w ithin the appli cant ins ti tutio n (Sc hools of B us ine s s , E conom ics , Law, Pub lic P olicy, Soc ial S cienc es , P ublic Heal th, C om m un icati ons , etc.) with the poten tial for m utual bene fit s uc h as learn ing b us ine s s s k ills , s pec ific cours es in cludi ng ha nds -o n tra ining in techno logy trans fer, pro gram or po licy devel opm en t, m a nagem ent a nd ad m inis trati on at gove rnm en t age ncies (Fed eral, s tate, and loca l governm e nts , etc.) , and inte rns hi ps or othe r col labor ation s with par tner com pa nies or other

ins titutions . Appl icants s ho uld i nclud e details on th e rel ation s hips /partners h ips they a re pr opos i ng wi th par ticul ar attenti on to what the parti cipan ts wi ll do duri ng th es e e xperi ences .

It is expecte d tha t the BEST awar ds wi ll tr ans ce nd de partm ent, progr am , a nd po s s ibl y s ch ool b ounda ries , and be a vaila ble to bio m edic al s c ience grad uate s tude nts a nd po s tdoc s acr os s d is cip lines . The y s ho uld aim to trans form the cu lture of r es ear ch tr ainin g in the b iom ed ical s cien ces for bo th pa rtici pants and m en tors and d is s em inate find ings widel y acr os s the tr ainin g com m unity. Ap plica tions that leve rage funds fro m thi s pro gram with exis ting i ns titution al offices and progr am s , local res o urces outs ide the in s titu tion, or par tners are highl y enc ourag ed.

The trai ning perio d for biom edica l car eers is al ready leng thy, and thes e activities s hou ld be inte grate d with tra ditio nal traini ng s o as n ot to incr eas e the tim e to deg ree for pr edoctoral s tude nts o r the leng th of the

pos tdoctoral perio d.

The BEST awar ds ar e m ea nt to be e xperi m ents and there fore rigor ous e valua tion of ea ch in divid ual a ward wil l be requi red b y both the indi vidua l awa rdees and indep enden tly b y NIH . For NIH’ s eva luati on pl an, awa rdees will be r equir ed to provide d ata i nclud ing, but n ot li m ited to, infor m atio n s pe cifie d in the e valua tion pla n bel ow. N IH expects that appr oache s tha t are tes ted an d pro ven to be s ucce s s ful will be w idely

dis s em in ated throu ghout the biom e dical trai ning com m u nity. A fu rther expe ctati on is that the newly develope d tra ining acti vitie s fro m the s e aw ards that are d eem ed s ucc es s fu l wil l be ins ti tutio nalized.

In order to p reven t und ue re dunda ncies and to s h are i nform ation and bes t practices , the BEST award ees w ill interact on a regu lar b as is . Each year , awa rdees will m eet to d is cus s developm ents , prog res s and i ns igh ts gai ned. Appli cants s hou ld bu dget for p artic ipati on at thes e m ee tings . The Prog ram D irector/Pr incip al Inves tig ator (PD/P I) an d rel evant pers onnel s hou ld be prep ared to attend the a nnual m eetings in Be thes d a, MD, s tar ting with the s econd annu al m e eting Octo ber 3 0-31, 2014 . Per iodic tele confe rence call s wil l

aug m ent inter actio ns am ong the aw ardee s , an d s ite vis its from N IH s taff w ill e valua te pr ogres s of the pro gram as it deve lops .

BES T pro gram s m ay com pl em ent ongo ing r es ear ch tr ainin g and educ ation occu rring at the ap plica nt

ins titution, but the pr opos e d BES T exp erien ces m us t b e dis tinct from thos e tra ining and educa tion progr am s cur rentl y rec eivin g Fed eral s uppo rt. D P7 pr ogram s m ay augm ent i ns titution al re s earc h tra ining prog ram s (e.g., T32, T90) b ut ca nnot be us ed to repl ace o r cir cum ve nt Ru th L. Kirs chs te in Na tiona l Res earch Service Awa rd (N RSA) progr am s .

_{Section II. Award Information}

Funding Instrument	Gra nt: A s upp ort m echan is m p rovid ing m oney, prop erty, or b oth to an eli gible enti ty to carr y out an a pproved pr oject or a ctivi ty.
Application Types Allowed	New The OER Glos s ary a nd th e SF4 24 (R &R) Applic ation Guid e pro vide details on th es e a pplic ation type s .
Funds Available and Anticipated Number of Awards	NIH Com m on Fu nd in tends to c om m it appr oxim a tely $3,00 0,000 in FY 201 4. Ap proxi m atel y 7-1 0 awa rds a re an ticip ated, contingen t upo n ava ilabi lity of fu nds a nd re ceipt of a s ufficien t num ber o f
Award Budget	Awa rds w ill b e for up to $25 0,000 in d irect cos ts per year , plu s app licab le Fac iliti es an d Adm inis trative (F& A) co s ts .
Award Project Period	The requ es ted proj ect p eriod m ay not e xceed five year s . Th e pur pos e of thi s awa rd is to s uppor t the deve lopm e nt of prog ram s but n ot to m ain tain the m after 5 years .

_{Other Award Budget Information}

Personnel Costs

Ind ividu als d es ign ing, direc ting, and im ple m enti ng th e BES T pro gram m ay requ es t s alary and fring e ben efits appr opria te fo r the pers on m o nths devoted to th e pro gram . Sala ries reque s ted m ay n ot exceed the l evels com m ens u rate with the i ns titution 's po licy for s im ila r pos ition s and m ay not exce ed th e con gres s ional ly m a ndate d cap . (If m entoring inte racti ons and othe r activiti es wi th pa rtici pants are cons i dered a re gular part of a n ind ividu al's acade m ic d uties , the n any cos ts as s ociated wi th th e m en torin g and othe r interactions with parti cipan ts ar e not allo wable cos ts fro m gra nt fu nds ).

Participant Costs

Par ticip ants are the be nefic iarie s of this progr am , n am ely grad uate s tu dents and pos td octor al in divid uals . No funds from this award m ay be us e d to cover or s upple m ent wages or s tipen ds of thes e ind ividu als . Tui tion cos ts of thes e individual s are als o cove red b y oth er s o urces , and the refor e not allo wable unde r thi s awa rd. H oweve r, we ll ju s tifi ed tr avel of gra duate s tud ents and p os tdo ctora l s ch olars to p rogra m s ites is all owabl e. Exp ens es for forei gn tr avel m us t be excepti onall y wel l jus tifie d.

Other Program- Related Expenses

Con s ulta nt co s ts , equip m ent, s upp lies , travel fo r key pers ons , and o ther pro gram - related expens e s m ay be i nclud ed in the propo s ed b udget. The s e expens e s m us t be jus ti fied as s p ecifi cally requ ired by th e pro pos ed prog ram a nd m u s t no t dup licate ite m s ge neral ly availab le at the appl icant ins tituti on.

Gue s t s p eaker s , ou ts ide expe rts , cons u ltant cos ts , ad m inis trati ve per s onne l, an d oth er pr ogram -rela ted e xpens es m a y be inclu ded i n the pro pos ed budg et. Thes e expen s es m us t b e jus tifie d as s peci fical ly

	req uired by the pr opos e d pro gram and m us t n ot du plica te item s gen erall y ava ilabl e at the a pplic ant i ns titution . Awa rdees m us t budg et fo r attendan ce of rele vant pers o nnel at an annu al awa rdee m eeti ng s tartin g with the Octo ber 3 0-31, 2014 , ann ual m eetin g, to be he ld in Beth es da, MD. Expen s es a re no t to excee d $15 00 pe r per s on p er tr ip.
Indirect Costs	Ind irect Cos ts (al s o kn own a s Fac iliti es an d Adm inis trative [F& A] co s ts ) are reim burs e d on the b as is of a negotiated rate agre em ent.

NIH gran ts po licie s as des cr ibed in th e NIH Gran ts Po licy State m ent will apply to the ap plica tions s ubm itted and awar ds m a de in res p ons e to th is FOA.

Section III. Eligibility Information

1. Eligible Applicants

Eligible Organizations

Hig her E ducation Ins titution s

Pub lic/S tate Contr olled Ins tituti ons o f Hig her E ducation

Pri vate Ins ti tutio ns of High er Ed ucati on

The foll owing type s of Highe r Edu catio n Ins titutions are a lways enco urage d to apply for NIH s uppor t as

Pub lic o r Pri vate Ins ti tutio ns of High er Ed ucati on:

His panic -Serving Ins titution s

His toric ally Black Coll eges and U niver s itie s (HB CUs ) Tri bally Controlle d Col leges and Unive rs iti es (TCCUs ) Ala s ka N ative and Native Haw aiian Serving Ins titution s

As i an Am erica n Native Am eric an Pa cific Is la nder Servi ng In s titu tions (AAN APISIs )

Onl y PhD -degr ee gr antin g ins titutions are e ligib le to appl y. In s titu tions that rece ived a BES T awa rd in fis c al yea r 201 3 are not eligi ble to app ly.

Ins titutions with exis ting R uth L . Kir s chs tein N ation al Re s earc h Ser vice Award (NRS A) in s titu tiona l tra ining gra nts ( e.g., T32) or o ther Feder ally funde d tra ining prog ram s m ay a pply for a BEST Awar d pro vided that the pro pos ed educ ation al experie nces are d is tin ct fr om th os e traini ng pr ogram s rec eivin g fed eral s uppo rt. In m an y cas es , i t is antic ipate d tha t the prop os ed BEST progr am wi ll co m plem ent o ngoin g res earch trai ning occ urrin g at the a pplic ant i ns titution .

Foreign Institutions

Non -dom e s tic (non- U.S.) Enti ties (Fore ign Ins titution s ) ar e not elig ible to ap ply.

Non -dom e s tic (non- U.S.) com p onents of U.S. Organ izati ons a re not eli gible to a pply. For eign com po nents , as defin ed in the NIH Grants Poli cy Statem e nt, a re not all owed.

Required Registrations

Applicant Organiza tions

App lican t org aniza tions m us t com p lete and m ainta in th e fol lowin g reg is tra tions as d es cri bed i n the SF 4 24 (R& R) Ap plica tion Guide to b e eli gible to a pply for o r rec eive an aw ard. All r egis tratio ns m u s t be com p leted pri or to the appli catio n bei ng s u bm itted. R egis tratio n can take 6 we eks o r m or e, s o appl icants s ho uld b egin

the regi s tration p roces s as s oon as po s s ibl e. Th e NIH Poli cy on Late Subm is s io n of Grant Appl icati ons s ta tes that failur e to com pl ete r egis tratio ns in adva nce o f a d ue da te is not a val id re as on for a late

_{s ub m is s i on.}

Dun and Brads treet Univers al Num b ering Sys tem (D UNS) - All regi s trations requi re th at ap plica nts b e is s ued a DUNS num b er. After obtai ning a DUN S num ber, appli cants can begin both SAM and e RA Com m ons regis trati ons . The s am e D UNS n um ber m us t be u s ed for al l reg is tra tions , as well as on

the gran t app lication.

Sys tem for Aw ard Manage m ent (SAM) (for m erly CCR) – Ap plica nts m us t c om ple te an d m ai ntain an active r egis tratio n, which r equir es re newal at least annua lly. The r enewa l pro ces s m ay r equir e as m uc h tim e as the i nitia l reg is tra tion. SAM regis trati on in clude s the as s i gnm en t of a Com m erci al an d Governm e nt En tity (CAGE ) Cod e for dom e s tic organ izati ons w hich have not a lread y bee n as s igned a CAGE Cod e.

NATO Com m erci al an d Governm e nt En tity (NCAGE) Co de – Forei gn or ganization s m us t obtain a n

NCAGE co de (i n lie u of a CAGE cod e) in orde r to regis ter i n SAM.

eRA Com m ons - Appl icants m us t have an active DUN S num ber a nd SAM reg is tra tion in or der to

com plete the eRA C om m on s reg is tra tion. Orga nizations can r egis ter wi th th e eRA Com m ons a s the y are work ing throug h the ir SAM or Grants .gov regi s tration. eRA C om m on s req uires orga nizations to ide ntify at l eas t one S ignin g Official (SO) and at le as t o ne Pr ogram Dire ctor/Princ ipal Inves tigator (PD /PI) accou nt in orde r to s ubm i t an appli catio n.

Gra nts .g ov – Appli cants m us t have an a ctive DUNS num b er an d SAM regi s tration i n ord er to com p lete the Gran ts .go v reg is tra tion.

Program Direc tors/Princ ipal Inves tigat ors ( PD(s) /PI(s ))

All PD(s )/PI( s ) m u s t ha ve an eRA Com m o ns ac count and s houl d wor k with the ir or ganization al officia ls to either c reate a ne w acc ount or to affi liate an e xis ti ng ac count with the appli cant organ izati on’s eRA

Com m ons accou nt. If the PD/P I is als o the o rgani zatio nal S ignin g Official , the y m us t have two dis tinct eRA Com m ons accou nts , one for ea ch ro le. Obtain ing a n eRA Com m ons a ccoun t can take up to 2 w eeks .

Eligible Individuals (Program Director/Principal Investigator)

Any indi vidua l(s ) with the s kills , kno wledg e, an d res ource s nec es s ar y to carry out the p ropos ed re s earc h as the Prog ram D irector(s ) /Prin cipal Inve s tiga tor(s ) (PD (s )/P I(s )) is i nvite d to work with his /h er or ganization to develop an ap plica tion for s uppor t. In divid uals from diver s e ba ckgro unds , incl uding unde rrepr es ented ra cial and ethn ic gr oups , indi vidua ls wi th di s abil ities , and wom e n are alwa ys en coura ged to app ly fo r NIH s upp ort.

For ins tituti ons /o rgani zatio ns pr opos i ng m u ltipl e PDs /PIs , vis i t the Multiple Progr am Di recto r/Pri ncipa l Inves tig ator Polic y and s ubm is s io n details in th e Sen ior/K ey Pe rs on Profi le (E xpand ed) C om pon ent o f the SF4 24 (R &R) Applic ation Guid e.

The PD/P I s ho uld b e an es tab lis he d inves tig ator in th e s ci entific ar ea in whic h the appl icati on is targ eted and capa ble o f pro vidin g both adm inis trative and s cie ntifi c lea ders h ip to the devel opm en t and im p lem en tatio n of the p ropos ed pr ogram . The PD/P I wil l be expec ted to m on itor and a s s es s the progr am and s ubm it al l doc um ents and repo rts a s req uired .

2. Cost Sharing

Thi s FOA does not requi re co s t s h aring as d efine d in the N IH Gr ants Polic y Sta tem en t.

3. Additional Information on Eligibility

Number of Applications

Onl y one appl icati on pe r ins titution ( norm a lly i denti fied by ha ving a uni que D UNS n um ber or N IH IP F

num ber) is al lowed .

NIH will not accep t any appl icati on th at is es s e ntial ly th e s am e as one a lread y reviewed with in th e pas t thi rty- s even m o nths (as d es cri bed i n the NIH Grants Pol icy S tatem ent), exce pt fo r s ub m is s i on:

To an RFA of an ap plica tion that was s ubm itted p revio us ly as an inve s tiga tor-i nitia ted a pplic ation but not paid ;

Of an in ves ti gator -initiated appl icati on th at wa s ori ginal ly s u bm itted to an R FA bu t not paid ; or

_{Of an ap plica tion with a cha nged grant acti vity code.}

Program Faculty

Awa rdees are encou raged to r ecrui t ind ividu als w ith a pprop riate expe rtis e from dive rs e b ackgr ounds , inc ludin g rac ial a nd ethnic m inor ities , per s ons with dis ab iliti es , a nd wo m en a s dir ector s /m en tors /teach ers /l ectur ers /p recep tors . Mentors s hould have res e arch exper tis e and/o r exp erien ce rel evant to the pr opos e d pro gram and a dem o ns tra ted h is tor y of excel lence in this a rea. Award ees a re enc ourag ed to recr uit a nd s u pport indi vidua ls ac ting in th e pro gram from partn er or ganization s rep res en ting a variety of caree r options .

Participants

Unl es s s trong ly ju s tifi ed on the bas is of e xceptional rele vance to N IH, B EST p rogra m s s h ould be us ed pri m aril y for the educa tion of U.S. ci tizen s and perm anent res i dents . In divid uals who a re ne ither U.S. citizens nor perm a nent res id ents m ay p artic ipate in the BE ST pr ogram plan acti vitie s , bu t as s ociated co s ts m us t be well jus ti fied.

Section IV. Application and Submission Information

1. Reque sting an Application Package

App lican ts m u s t do wnloa d the SF42 4 (R& R) ap plica tion packa ge as s ocia ted w ith this fundin g opp ortun ity us i ng th e “Ap ply for Gr ant E lectr onica lly” butto n in this FOA o r fol lowin g the dire ction s pro vided at Grants .gov.

2. Conte nt and Form of Application Submission

It is cr itica l tha t app lican ts fo llow the i ns tru ction s in the S F424 (R&R) Appl icati on Gu ide , excep t whe re

ins tructed in this fund ing o pportunity anno uncem ent to do other wis e. Conform an ce to the requi rem en ts in the Appl icati on Gu ide i s req uired and s tric tly e nforc ed. Applic ation s tha t are out of co m plia nce w ith thes e ins tructions will not b e reviewed .

For info rm ati on on Appl icati on Su bm is s ion a nd Re ceipt, vis it Fr equen tly As ked Ques tions – App lication

Gui de, E lectr onic Subm i s s ion of Grant Appli catio ns .

Letter of Intent

Although a le tter of in tent is no t req uired , is not b indin g, an d doe s not ente r into the revi ew of a s u bs equ ent app lication, the i nform ation that it c ontai ns al lows CSR s taff to es tim ate the pote ntial revi ew wo rkloa d and pla n the revi ew.

By the d ate l is ted in P art 1 . Ove rview Info rm ati on, p ros pe ctive appl icants are as ke d to s ubm i t a l etter of i ntent tha t inc ludes the follo wing infor m atio n:

Des criptive title of pr opos e d activity

Nam e(s ), addr es s (e s ), a nd te lepho ne nu m ber( s ) of the PD(s ) /PI(s ) Nam es of othe r key pers onnel

Par ticip ating ins tituti on(s )

_{Num ber a nd ti tle o f thi s fun ding oppor tunity}

The letter of inte nt s h ould be s e nt to :

Dr. Patr icia Labos ky

Pro gram Leade r

Office o f Str ategi c Coo rdina tion

Divis ion of P rogra m Coo rdina tion, Plan ning and S trate gic Initia tives

Office o f the Dire ctor, NIH

1 C enter Drive, Ro om 21 4A Bethes da , MD 20892 -0189

Tel ephon e: 30 1-594 -4863

Em a il: l abos k ypa@o d.nih .gov

Page Limitations

All page lim i tatio ns de s crib ed in the SF424 (R&R ) App lication Guide and the Ta ble o f Pag e Lim its m us t b e fol lowed , with the foll owing addi tiona l ins tructions :

BES T Pro gram Plan (uplo aded via R es ear ch Strateg y): 2 5 pag es .

Required and Optional Components

The form s pac kage as s oc iated with this FOA inclu des a ll ap plica ble c om pon ents , requ ired and o ption al. Ple as e n ote that s om e c om pon ents m arke d optional in the ap plica tion packa ge ar e req uired for s ubm i s s ion of appli catio ns fo r thi s FOA. Fol low the in s truc tions in the SF424 ( R&R) Appli catio n Gui de to ens u re yo u

com plete all appro priate “op tiona l” co m pone nts .

Instructions for A pplication Submission

The foll owing s ection s upple m ents the ins tr uctio ns fo und i n the SF42 4 (R& R) Ap plica tion Guide and s houl d be us ed for p repar ing a n app lication to thi s FOA.

SF4 24(R&R) Cover

Fol low a ll in s truc tions provided in th e SF4 24 (R &R) Applic ation Guid e.

SF4 24(R&R) Project/Performance Site Locations Fol low a ll in s truc tions provided in th e SF4 24 (R &R) Applic ation Guid e. SF4 24 (R &R) Other Project Information Component

Fol low a ll in s truc tions provided in th e SF4 24 (R &R) Applic ation Guid e with the foll owing addi tiona l

m od ifica tions :

Fac ilities & Other Resources . Des cribe the educa tiona l and trai ning envir onm en t, bo th at the ins ti tutio n and , whe re ap plica ble, at other r eleva nt s i tes , inclu ding the facili ties , labo rator ies , parti cipating dep artm e nts , com pu ter s ervic es , a nd an y oth er re s ourc es to be u s ed i n the deve lopm e nt an d im p lem en tatio n of the p ropos ed pr ogram . Lis t all them atica lly r elate d s ou rces of s u pport for res ea rch tra ining and educa tion follo wing the form at for Curre nt an d Pen ding Suppo rt. The s pons o ring ins ti tutio n m us t as s ure s uppor t for the propo s ed p rogra m .

Other At tachm ents. A pl an m u s t be provided for the ap pointm ent of an Advi s ory Com m i ttee that will eva luate the propo s ed p rogra m , its im p lem en tatio n and its progr es s . The C om m ittee s hould have the authority to recom m end any m id-co urs e chang es ne eded to en hance the progr am . C om pos ition ,

res pons i bilities , frequ ency of m e eting s , an d oth er re levan t inform ation s hould be i nclud ed. D es cri be th e com pos ition o f the Advi s ory Com m i ttee, iden tifyi ng th e rol e and the des ir ed experti s e of m em b ers .

Des cribe how the Advis o ry Co m m ittee wi ll fu nctio n in provi ding overs ight of th e developm ent, im p lem en tatio n, an d eva luati on of the overa ll effecti venes s of the p rogra m . No te th at pr opos e d Advis ory Com m itte e m em bers s houl d be nam ed in the ap plica tion, particula rly i f the y inc lude individual s fro m outs ide the i ns titution . It is expecte d tha t the Advi s ory Com m i ttee will inclu de re pres e ntati ves from outs ide the a cadem ic co m m uni ty. P leas e nam e your file “Advis ory_Com m ittee .pdf” .

The file nam e provi ded for ea ch “Other Attac hm ent” wil l be the n am e u s ed for th e boo km ark in the ele ctron ic ap plica tion in eR A Com m ons .

SF4 24(R&R) Senior/Key Person Profile Expanded Fol low a ll in s truc tions provided in th e SF4 24 (R &R) Applic ation Guid e. R&R Budget

Fol low a ll in s truc tions provided in th e SF4 24 (R &R) Applic ation Guid e with the foll owing addi tiona l

m od ifica tions :

Inc lude all p ers on nel o ther than the P D(s )/PI(s ) in the Other P ers on nel s ectio n, in cludi ng cl erica l and adm inis trative s ta ff.

PHS 398 Cover Page Supplement

Fol low a ll in s truc tions provided in th e SF4 24 (R &R) Applic ation Guid e.

PHS 398 Research Plan Component

All ins tructi ons i n the SF42 4 (R& R) Ap plica tion Guide m us t be follow ed, w ith the fo llowi ng ad ditio nal ins tructions :

Research Strategy

The Rese arch Strat egy s ectio n m us t be us ed to up load the BEST P rogra m Pla n, wh ich m us t i nclud e the fol lowin g com ponen ts de s crib ed be low:

Pro pos ed BEST Prog ram

Pro gram Direc tor/P rinci pal Inves tigato r(s ) Pro gram Facul ty/Staff

Pro gram Parti cipan ts

Ins titutional Envi ronm e nt an d Com m itm e nt Divers ity Rec ruitm ent a nd Re tenti on Pl an Eva luati on Pl an

_{Dis s em in ation Plan}

BES T Program Plan

Proposed BEST Program. Des cr ibe the BE ST pr ogram ’s s p ecifi c pur pos e, s hor t-ter m , in term e diate , and long -rang e goa ls , a s wel l as inten ded o utcom es . E xplai n the bas i s and rati onale for the p rogra m and any evide nce o f pas t s uc ces s upon which it m ay be bas e d. De s crib e the educ ation al le vel ( pre and /or p os t g radua te de gree, if a pplic able) of the pa rtici pants , and the am oun t of their participa tion (ho urs s pent over how m uch tim e). Des c ribe in de tail any n ew bu s ines s and /or a cadem ic m o dels that wil l be utili zed to rec ruit, adm i t, s u pport, and s tee r s tu dents and pos td octor al s c ienti s ts to better p repar e the m for chos en ca reers . Des cribe in d etail the activities of the pr ogram , inc ludin g any cour s es to be develope d, an d how thes e wil l be integ rated into the exis ting g radua te pr ogram . A tim eli ne m a y be us ed to clari fy ho w the prop os ed activities will not adver s ely im pac t tim e to degre e or tim e in th e pos tdoctoral pos ition . If the p lan w ill b e s ta rted with a s m a ller num be r of parti cipan ts an d the n exp anded , des cribe how this will be a ccom p lis he d. De s crib e how the progr am wi ll s p an de partm ental , cen ter, progr am and /or s chool boun darie s to poten tiall y rea ch al l bio m edic al gr aduate s tu dents and pos td octor al ind ividu als . Des cr ibe h ow th e pro gram will be evaluated an d, s p ecifi cally, the evid ence and d ata to be col lecte d for this eval uatio n. In particula r, de s crib e the plan s for trac king the p rogra m par ticip ants while in the p rogra m , bu t als o the im m e diate next care er s tep of PhD gradu ates and o f s ci entis ts co m pleting the ir po s tdoc toral expe rienc e (us ually no m ore than 5 year s dur ation ) and m ovi ng in to s u bs equ ent

pos ition s . De s crib e how indi vidua ls wi ll ha ve ac ces s to th e pro gram acros s dep artm e ntal, prog ram , cen ter a nd/or s cho ol bo undar ies . Des cr ibe h ow th e m en tors of th e par ticip ants will be en gaged and

how they will im pa ct th e pro gram (facu lty b uy-in ). De s crib e how the activities and “les s ons l earne d” of thi s pro gram will be di s s em i nated to b enefi t all biom edica l s tu dents and pos td octor al fe llows at the ins titution. Des cr ibe h ow s u cces s ful a pproa ches will be pu blici zed a nd di s s em i nated to o ther

ins titutions . If p artic ipants are to travel to p artne r s ites , d es cri be wh at th e par ticip ants will do at thes e

s ites an d des cribe the exter nal p artne rs ’ c om m itm ents to the pa rtici pants befo re, d uring , and afte r the ir off-s ite trai ning exper ience .

Ins titutions that are c urren tly e xplor ing n ovel appro aches are encou raged to a pply but m us t c arefu lly exp lain how s uppor t fro m thi s awa rd wo uld s ubs ta ntial ly co m plem ent a nd/or add new d im ens ions to the ir exis tin g pro gram s . App lications that reque s t ad ditio nal s uppor t onl y to m aintain a n exi s ting

pro gram will be de em ed non-r es pon s ive. Exam ples of in novative a pproa ches inclu de bu t are not lim ited to: exch ange arran gem en ts wi th other s chool s and prog ram s withi n the appl icant ins tituti on (S chool s of Bus ines s , Eco nom ic s , La w, Pu blic Polic y, So cial Scien ces , Publi c Hea lth, Com m u nications , etc.) with the pote ntial for m utua l ben efit s uch as le arnin g bus ines s s kil ls , s pecific co urs es incl uding hand s -on tra ining in techno logy trans fer, progr am or poli cy de velop m ent, m ana gem en t and adm i nis tr ation at governm e nt ag encie s (Fe deral , s ta te, a nd lo cal g overn m ents , etc .), a nd in terns hips or other col labor ation s with par tner com pa nies or other i ns titution s . Ap plica nts s hould incl ude d etail s on the rel ation s hips /partners h ips they a re pr opos i ng wi th pa rticu lar a ttention to wha t the participa nts w ill d o dur ing thes e exper ience s .

Program Direc tor/P rincipal Invest igator. De s crib e arr angem ents for a dm ini s tration o f the prog ram . Pro vide evide nce that the Pr ogram Dire ctor/Princ ipal Inves tigator is acti vely engag ed in res e arch, tra ining and/or te achin g in an ar ea re lated to the m i s s ion of N IH, a nd ca n org anize , adm inis ter, m onito r, and eval uate the B EST p rogra m . Fo r pro gram s prop os ing m ultiple PDs /P Is , d es cri be th e

com plem e ntary and integ rated expe rtis e of the PD s /PIs , the ir le aders hip a pproa ch, a nd go verna nce app ropri ate for th e pla nned proje ct.

Program Faculty. R es ear chers from dive rs e b ackgr ounds , inc ludin g rac ial a nd ethnic m inor ities , per s ons with dis ab iliti es , a nd wo m en a re en coura ged to par ticip ate a s pro gram facul ty. Faculty s ho uld have res earch expe rtis e and exper ience rele vant to th e pro pos ed prog ram a nd de m ons trate a his tory of, or the p otential for, their inten ded r oles . Des c ribe the c urren t res pons i bilities o f the participa ting facul ty and othe r exp ert s taff who w ill c ontri bute to th e s uc ces s of th is pr ogram . Pro vide evide nce that the par ticip ating facu lty s uppor t thi s pro gram and the s tudents and pos tdocs who w ill p artic ipate in this pro gram ; this m ay be pr ovide d via letters o f s up port and/o r ros ters of fa culty who will allow thei r

s tu dents /pos tdocs to pa rtici pate in th e BES T pro gram activities .

Program Participants. Applic ation s m us t des cribe the inten ded p artic ipants , an d the elig ibili ty cr iteri a and /or s pecific ed ucati onal backg round char acter is tic s tha t are es s e ntial for parti cipation i n the pro pos ed BEST prog ram . Identify the ca reer level s for whic h the prop os ed progr am is plan ned.

Ins titut ional Environme nt and Com mitme nt. D es cri be th e ins titutional envi ronm e nt, r eiter ating the ava ilabi lity of fa cilities a nd ed ucati onal res ou rces (des c ribed s epa ratel y und er “Facili ties & Oth er

Res ource s ”), that can c ontri bute to th e pla nned BEST Progr am . E viden ce of ins tituti onal com m i tm ent to the BEST prog ram i s req uired . A l etter of i ns titution al co m m itm ent m us t b e attached as p art o f Letters of Sup port (s ee below ). Ap propr iate ins ti tutio nal c om m itm ent s houl d inc lude the p rovis ion o f ade quate s ta ff, facili ties , and educa tiona l res ource s tha t can contribute to the p lanne d BES T pro gram . The lette r of ins titutional com m itm en t m us t als o add res s the l ong-term c om m itm ent to th e goa ls of the progr am an d

anticipa ted p lans for c ontin uatio n of the n ovel curri cula, inte rns hi ps , e tc. a fter they are d evelo ped throug h thi s pro gram . Des c ribe how the in s titu tiona l com m itm e nt re flects the expe ctati on th at gr aduate s tu dents and pos tdocto ral fellow s (re gardl es s o f the ir s a lary s uppo rt m e chani s m s ) will be al lowed to p artic ipate . Des cribe how ins ti tutio ns wi ll in tegra te th es e a ctivi ties into exis ting p rogra m s fo r gra duate s tud ents and pos tdoctoral fello ws . If par tner organ izati ons a re expecte d to provi de lo ng-te rm s u pport via the par ticip ation of their s taff and/or th e s up port of in terns hips or other traini ng op portu nitie s , le tters of s up port from thes e orga nizations m us t als o be in clude d.

Diversit y Rec ruitm ent a nd Re tention Plan. The NIH rec ognizes a uniqu e and com p ellin g nee d to pro m ote diver s ity (am on g US Citizens a nd pe rm ane nt re s iden ts ) i n the biom edica l, be havio ral, clini cal

and s oci al s c ience s res earch work force . The NIH expec ts efforts to d ivers ify the wo rkfor ce to lead to the rec ruitm ent o f the m os t tale nted res ea rcher s fro m all grou ps ; to im p rove the q uality of the e ducational and trai ning envir onm en t; to bala nce a nd br oaden the pers p ective in s etti ng re s earc h pri oriti es ; to im p rove the a bility to recru it s u bjects fro m divers e backg round s into cli nical res e arch proto cols ; and to im p rove the N ation 's ca pacity to addre s s an d eli m inate hea lth d is par ities . The BEST prog ram w ill d raw fro m the ins tituti on's pool of gr aduate s tu dents and pos td octor al fe llows (whe re ap plica ble). This pre s ents an o pportunity for appli cants to e ngage in targeted re cruitm ent effor ts to enha nce the di vers i ty of the p ool o f par ticip ants in th e pro gram . Appl icants s ho uld d es cri be ho w the y pla n to attra ct s tudents fro m und errep res en ted b ackgr ounds to p artic ipate in B EST a ward activities .

Acc ordin gly, the N IH co ntinu es to enco urage ins tituti ons to divers ify the ir s tudent and facul ty po pulations and thus to i ncrea s e th e par ticip ation of i ndivi duals curr ently unde rrepr es ented in the biom e dical , cli nical , beh avior al, a nd s o cial s cien ces s uch a s : in divid uals from under repre s ente d rac ial a nd ethnic gro ups ; individual s with dis abili ties ; and individual s fro m s oc ially, cul tural ly, e conom icall y, or edu catio nally dis a dvantaged backg round s tha t have inh ibite d the ir ab ility to p urs ue a ca reer in he alth- rel ated res ea rch. Ins ti tutio ns ar e enc ourag ed to iden tify candi dates who will incre as e d ivers ity o n a national bas i s .

The NIH is pa rticu larly inte res te d in encou ragin g the recr uitm e nt of the follo wing clas s es of participa nts : A. In divid uals from racia l and ethn ic gr oups that have been s hown by the Na tiona l Sci ence Found ation

to be un derre pres e nted in he alth- related s c ience s on a national bas i s (s e e data at http://w ww.ns f.gov/s tatis tic s /s ho wpub.cfm ?TopID= 2&Sub ID=27 and the m os t r ecent repo rt on Wom e n, Min oriti es , a nd Pe rs ons with Dis a bilities i n Sci ence and E ngine ering ). Th e fol lowin g rac ial a nd ethnic gro ups h ave b een s hown to be unde rrepr es ented in biom edica l res earch : Afr ican Am eri cans , His p anic Am e rican s , Na tive Am eri cans , Alas kan N ative s , Ha waiia n Natives , and natives of the U.S. Pacific Is l ands . In a dditi on, i t is recog nized that unde rrepr es entation can vary from s etti ng to s etting; individual s fro m rac ial o r eth nic g roups that can be co nvinc ingly dem o ns tra ted to be under repre s ente d by the gra ntee ins ti tutio n s ho uld b e enc ourag ed to participa te in this prog ram .

B. In divid uals with dis ab iliti es , w ho ar e defined as th os e w ith a phys ical or m e ntal im pai rm ent that s ub s tantially lim i ts on e or m ore m ajor life acti vitie s .

C. In divid uals from dis ad vanta ged b ackgr ounds who are d efine d as :

1. In divid uals who c om e from a fam i ly wi th an annu al in com e below es ta blis h ed lo w-inc om e thres h olds . The s e th res ho lds a re ba s ed o n fam ily s ize; publi s hed by th e U.S . Bur eau o f the Cens us ; a djus ted an nuall y for chan ges i n the Cons um er Price Inde x; an d adj us ted by the Se creta ry fo r us e in a ll he alth profe s s ion s pro gram s . The Secr etary peri odica lly p ublis hes thes e incom e levels a t HHS - Po verty Guid eline s , Re s earc h, and Meas urem e nt. For in divid uals from low i ncom e back groun ds , the in s titu tion m us t be ab le to

dem ons tr ate that s uch p artic ipants have (1) qual ified for Feder al di s adva ntage d as s is tan ce, ( 2) th ey ha ve rec eived Heal th Pr ofes s ions Stude nt Lo ans ( HPSL) or L oans for D is advantag ed Student Prog ram , or (3 ) the y have rec eived s cho lars h ips from the U.S. De partm ent o f Hea lth a nd Hu m an S ervic es un der the Sc holar s hip for Indi vidua ls wi th Excepti onal Finan cial Need.

2. In divid uals who c om e from a s oci al, c ultur al, o r edu catio nal e nviro nm ent s uch as that found in ce rtain rur al or inne r-city environm ents that have dem on s trab ly an d rec ently dire ctly inhib ited the i ndivi dual from obtainin g the know ledge , s ki lls , and a bilities n eces s ary to develop and p artic ipate in a res e arch- inten s ive or res earch -rela ted c areer .

Rec ruitm ent a nd re tenti on pl ans r elate d to a dis advan taged back groun d (C1 and C2) a re m o s t app licab le to high s cho ol an d per haps to un dergr aduate can didates , b ut wo uld b e m or e difficul t to jus ti fy for indi vidua ls be yond that level of a cadem ic ac hieve m ent. Unde r extraord inary circ um s ta nces the P HS m ay, at its d is cre tion, cons ider an in divid ual b eyond the under gradu ate l evel to be from a di s adva ntage d bac kgrou nd. S uch d ecis i ons w ill b e m ad e on a cas e-by- cas e bas is , bas ed on appr opria te doc um entation .

New appl icati ons m us t i nclud e a d es cri ption of p lans to en hance recr uitm e nt of a di vers e participa nt poo l and m ay wis h to in clude data in s uppor t of pas t accom plis h m ents . The plan s hou ld be appr opria te and reas onabl e for the natur e and dura tion of th e pro pos ed prog ram .

App lications lacki ng a diver s ity recru itm en t and rete ntion plan will not be re viewe d.

Eva luation Plan. The BE ST aw ards are m eant to be expe rim en ts an d the refor e rig orous eval uatio n of eac h ind ividu al aw ard w ill b e req uired by b oth the in divid ual a warde es an d ind epend ently by N IH. App lications m us t inclu de a detai led p lan for evaluating the ac tivities s uppor ted b y the awar d. The pl an s ho uld p rovid e inform ation that c learl y s ta tes w hat the pr ogram inte nds to do, what it h opes to acc om pli s h, a nd th e intended im pa ct of the progr am . The ap plica tion m us t s peci fy ba s elin e m etrics (e.g., n um ber s , ed ucati onal level s , an d dem ograp hic c harac teris tics of pa rtici pants ), as well as m ea s ures to g auge the s hort- or l ong-term i m pact of the BE ST pr ogram on the ca reer outco m es o f the par ticip ants . As a com p onent of this e valua tion, appl icants m us t obtain form al written feedba ck fr om par ticip ants , facu lty, and p artne rs ea rly a nd often to hel p ide ntify weak nes s e s and to p rovid e s ug ges ti ons for im prove m ents in the pr ogram .

App lications m us t inclu de pl ans for th e col lecti on of data to a ddres s the eval uatio n m ea s ures belo w. In par allel , the NIH will be ga theri ng th is in form a tion from award ees to con duct indep enden t eva luati ons o f the prog ram . The n ature of the pr opos e d pro gram m ight requ ire a dditi onal or di ffere nt da ta to be gathered , and the appli cants s hou ld pr opos e s uch addi tiona l data to be ga there d in their appl icati on. Note: da ta s h ould be ga there d at leas t annu ally or on a ro lling bas i s as appli cable .

Data to be ga there d by all a warde es :

Gra duate Stud ents:

Agg regate num ber a nd de m ogra phic chara cteri s tics of p artic ipants

Par ticip ation in a ctivi ties contr ibuti ng to the goals of the pr ogram (how m any s tud ents parti cipate, ho w m an y hou rs on aver age d o the y par ticip ate o ver w hat s pan o f tim e)

Attitude s tow ard, and u nders tandi ng of, car eer p aths addre s s ed by th e pro gram ; how attitudes and und ers ta nding are affec ted b y the prog ram

Per cepti on of s tud ents regar ding facul ty attitud es to ward s tude nt pa rtici patio n in the p rogra m

Pro ducti vity of pa rtici patin g s tu dents (inc ludin g pub lications and tim e to deg ree(s )) Gra duate degr ee(s ) obta ined

Sub s eque nt im m edia te jo b pla cem en t or pos td octor al ac tivity, in cludi ng po s tdoc toral m entor Inform ation o n gra duate s tud ents who p urs ue d oth er de gree progr am s a s a r es ult of this p rogra m ’s gui dance , inc ludin g whe n dur ing the tr ainin g per iod this c hange of track took place

Cur rent fundi ng s u pport (e.g ., NIH R01 , NRS A, NS F, HH MI, s ociety fel lows h ips )

_{Pos tdoctoral Scien tists :}

Agg regate num ber a nd de m ogra phic chara cteri s tics of p artic ipants

Deg ree o f par ticip ation in a ctivi ties contr ibuti ng to the goals of the pr ogram

Attitude s tow ard, and u nders tandi ng of, car eer p aths addre s s ed by th e pro gram ; how attitudes and und ers ta nding are affec ted b y the prog ram

Per cepti on of pos tdocto ral fellow s reg ardin g res earch facu lty a ttitu des toward participa tion in th e pro gram

Pub lications durin g the pos tdocto ral e xperi ence

Sub s eque nt co m peti tive caree r developm ent o r res earch s upp ort ( F32, K08, K99/R 00, founda tions , HHMI, etc.), or ho w par ticip ants are c urren tly s uppor ted

Detailed occu patio n inform ation, inclu ding next im m ed iate job a fter the p os tdo ctora l exp erien ce

Num ber o f yea rs in the pos td octor al experie nce b efore obta ining next pos i tion

_{Fac ulty:}

Num ber o f fac ulty from appli cant and p artne r ins titutions who p artic ipate as m entor s , in s truc tors , pre cepto rs fo r the trai ning activities deve loped thro ugh p rogra m

Num ber o f fac ulty from appli cant ins ti tutio ns wh o par ticip ate b y vir tue o f having s tuden ts an d/or pos tdocs from thei r lab orato ries engag ed in trai ning activities of the pr ogram

Deg ree o f fac ulty parti cipation i n activiti es co ntrib uting to the go als o f the prog ram

Attitude s tow ard p rogra m tra ining goal s and tim e of s tuden ts s p ent o uts id e the labo rator y; ho w attitude s cha nge a s a r es ult of the pr ogram

Pro jects in w hich an in ves ti gator obta ins d ata throug h interven tion or in terac tion with an in divid ual o r obtains identifiab le pr ivate info rm ati on, s uch a s with s ur veys or by trac king parti cipan ts , i s defined as hum an s u bjects res earch . Th es e a ctivi ties requi re th at th e app lication c laim Hum an Subj ects , even tho ugh i t is quite like ly th at th e pro ject falls into one of th e Exe m pt H um an Res ea rch c atego ries . App lican ts s h ould work with their ins tituti onal Revie w Boa rd (IRB) to obtain the re quire d exe m ptio ns or app roval s .

Dis semination Plan. A s pecific pl an m u s t be provided to di s s em i nate natio nally any findi ngs r es ulting fro m or m ater ials devel oped under the aus pi ces o f the BEST prog ram , e.g., s har ing c ours e curr icula web pos tings , pres entations or exhibit booths at s cie ntifi c m ee tings , wor ks hop s , te acher profes s io nal developm ent p rogra m s or Info rm ati on Sh aring Envi ronm e nts ( ISE)/m edia even ts .

Letters of Support

A l etter of i ns titution al co m m itm ent m us t b e attached as p art o f Letters of Su pport (s ee s ection a bove:

”Institutiona l Environm ent a nd Commitm ent.” ) Letters from partn ers m us t a ls o b e inc luded . App ropri ate ins titutional com m itm en t to the p rogra m inc ludes the provi s ion of ad equate s ta ff, facili ties , and edu catio nal r es our ces that c an co ntrib ute to the plan ned p rogra m . The in s titu tion m us t clear ly s tate

the ir s u pport of g radua te s tudent and pos td octor al fe llow parti cipation, regar dles s of s alary s upp ort m ec hanis m .

Resource Sharing Plans

Ind ividu als a re re quire d to com pl y with the ins tructi ons for th e Res ource Shar ing P lans (Data Shar ing Pla n, Sh aring Mode l Org anis m s , an d Gen om e Wide As s oci ation Stud ies ( GWAS) ) as provi ded i n the SF4 24 (R &R) Applic ation Guid e, wi th th e fol lowin g m od ifica tions :

Whe n rel evant, app lications are e xpected to incl ude a s oftware dis s e m ination p lan i f s up port for developm ent, m aintenanc e, or enha ncem e nt of s oftware is re ques ted in the appli catio n. There is no pre s crib ed s i ngle licen s e fo r s oftware prod uced. Howe ver, the s oftwa re di s s em i natio n pla n s ho uld add res s , as a pprop riate , the foll owing goal s :

Software s our ce co de s h ould be fr eely avail able to bi om edi cal r es ear chers and educa tors in th e non - pro fit s ector , s uc h as ins ti tutio ns of educ ation , res earch ins tituti ons , and g overn m ent labor atori es . Us e rs s h ould be pe rm itted to m odi fy th e cod e and s har e the ir m o dific ation s with oth ers .

The term s of s oftw are a vaila bility s ho uld p erm it the com m e rcial izati on of enha nced or cu s tom i zed ver s ions of the s o ftwar e, or inco rpora tion of th e s oftware or p ieces of i t into oth er s o ftwar e pac kages . To pres e rve u tility to the c om m un ity, the s oftwa re s h ould be tr ans fe rable s uch that another i ndivi dual or team can c ontin ue de velop m ent in th e eve nt th at th e ori ginal inve s tiga tors are u nwill ing o r una ble to do s o .

Appendix

Do not u s e th e App endix to c ircum vent page lim its . Fo llow all i ns tru ction s for the Appen dix a s des cribe d in the S F424 (R&R) Appl icati on Gu ide.

Planned Enrollment Report

Whe n con ducti ng cl inica l res earch , fol low a ll in s truc tions for com pl eting Plan ned E nroll m ent Repor ts as des cribe d in the S F424 (R&R) Appl icati on Gu ide.

PHS 398 Cumulative Inclusion Enrollment Report

Whe n con ducti ng cl inica l res earch , fol low a ll in s truc tions for com pl eting Cum u lative Inc lus io n Enr ollm e nt

Rep ort a s des cribe d in the S F424 (R&R) Appl icati on Gu ide.

3. Submission Date s and Time s

Par t I. Overview Inform ation contains infor m atio n abo ut Ke y Dates . Applic ants are e ncour aged to s u bm it app lications befor e the due date to en s ure they have tim e to m a ke an y app lication c orrec tions that m igh t be nec es s ar y for s ucc es s fu l s ub m is s i on.

Org aniza tions m us t s ubm it ap plica tions to Grants .gov (the onlin e por tal to fin d and appl y for gran ts ac ros s all Fede ral a genci es ). Appli cants m us t then com p lete the s ubm is s ion proce s s by trac king the s tatus of the app lication i n the eRA Com m o ns , N IH’s electronic s ys tem fo r gra nts a dm ini s tration.

Applicants ar e res ponsible f or viewing their applicat ion before the due date in the eRA Commons to ens ure a ccura te and suc cessf ul submiss ion.

Inform ation o n the s ubm is s io n pro ces s and a defi nitio n of on-ti m e s u bm is s ion a re pr ovide d in the S F424 (R& R) Ap plica tion Guide .

4. Intergovernmental Re view (E.O. 12372)

Thi s ini tiati ve is not s ubje ct to inte rgove rnm en tal r eview .

5. Funding Re strictions

All NIH award s are s ubj ect to the term s and cond ition s , co s t pr incip les , and o ther cons i derations des cr ibed in the N IH Gr ants Polic y Sta tem en t.

Pre -awar d cos ts ar e all owabl e onl y as des cr ibed in th e NIH Gran ts Po licy State m ent.

6. Other Submission Requirements and Information

App lications m us t be s u bm itted el ectro nical ly fo llowi ng th e ins tructions des cr ibed in th e SF4 24 (R &R) App lication Guide. Pap er ap plica tions will not be ac cepte d.

Applicants must complet e all required regis trations before the application due date . Sec tion III. Eligi bility

Inform ation c ontai ns in form a tion about regi s tration.

For as s i s tanc e with you r ele ctron ic ap plica tion or fo r m or e inform ation o n the elec troni c s ub m is s i on pro ces s , vis i t App lying Elec troni cally.

Important rem inder s:

All PD(s )/PI( s ) m u s t in clude thei r eRA Com m ons ID in the C reden tial field of the Se nior/Key P ers on Pro file Com po nent of th e SF4 24(R& R) Ap plica tion Packa ge. Failur e to regis ter i n the Com m ons a nd to inc lude a val id PD /PI C om m on s ID in th e cre denti al fi eld w ill p reven t the s ucc es s fu l s ub m is s i on of an ele ctron ic ap plica tion to NIH.

The appl icant orga nization m us t e ns ure that the DUNS num be r it provi des o n the appl icati on is the s am e num ber u s ed i n the orga nization’s profile i n the eRA Com m o ns an d for the Sys te m for Awar d Man agem e nt (S AM). Additional info rm ati on m a y be found in the SF424 ( R&R) Appli catio n Gui de.

See m ore tips for avoid ing c om m on erro rs .

Upo n rec eipt, appl icati ons w ill b e eva luate d for com p leten es s b y the Center fo r Sci entific Re view and

res pons i venes s by com po nents of p artic ipati ng or ganization s , NIH. Ap plica tions that are incom plete and/or

non res po ns ive will not be re viewe d.

Post Submission Materials

App lican ts ar e req uired to follow the ins tr uctio ns fo r pos t-s ub m is s i on m a teria ls , a s des cribe d in NOT-OD-

13- 030.

Section V. Application Review Information

1. Crite ria

Onl y the revi ew cr iteri a des cribe d bel ow wi ll be cons idere d in the r eview proc es s . As pa rt of the NIH m is s io n, all appl icati ons s ubm itted to the NIH in s u pport of b iom ed ical, beha viora l, an d cli nical res e arch are

eva luate d for s cie ntifi c and tech nical m eri t thr ough the N IH pe er re view s ys te m .

For this particula r ann ounce m ent, note the follo wing: The goal of th is BE ST pr ogram is to s up port res ea rch- rel ated train ing a ctivi ties that broad en gr aduate and pos tdocto ral traini ng, s uch that traini ng pr ogram s reflect the rang e of caree r options that thes e indi vidua ls (r egard les s of fu nding s our ce) u ltim a tely m ay p urs ue and tha t are requ ired for a robu s t bi om edi cal, behavioral , s oc ial a nd cl inica l res earch ente rpris e. Co llabo ratio ns with non acade m ic p artne rs ar e enc ourag ed to ens u re th at experts from a br oad s pectr um of res e arch- intens ive and res e arch- related ca reers contribute to cours ework , rotation s , in terns hips or other form s of exp os ure .

Overall Impact

Reviewer s wil l pro vide an overall im pa ct s c ore to reflect their as s e s s m en t of the l ikeli hood for the pr oject to s tr ongly adva nce r es ear ch ed ucati on by fulfillin g the goal of this B EST P rogra m , in cons idera tion of th e fol lowin g review c riter ia an d add ition al re view crite ria, as ap plica ble for th e pro ject propo s ed.

Scored R eview Criteria

Reviewer s wil l con s ider each of the re view crite ria b elow in th e determ in ation of s cientific m erit, and give a s ep arate s cor e for each . An appli catio n doe s not need to b e s tr ong i n all cate gorie s to be ju dged likel y to have m aj or s c ienti fic i m pact.

Significance

Doe s the prop os ed progr am ad dres s a ke y aud ience and an im porta nt as pect or im porta nt ne ed in res earch educ ation ? Is ther e con vinci ng evidenc e in the a pplic ation that the propo s ed p rogra m wil l s ig nific antly adva nce the s tated goal of th e pro gram ?

Investigator(s)

Is the P D/PI capab le of providing both adm i nis tr ative and s cien tific lead ers hi p to the d evelo pm ent and im p lem en tatio n of the p ropos ed pr ogram ? Is ther e evi dence that an a pprop riate leve l of effor t wil l be devoted by th e pro gram leade rs hip to e ns ure the progr am 's inten ded g oal i s acc om pli s hed? If app licab le, i s the re evidenc e tha t the participa ting facul ty ha ve experie nce i n m en torin g s tu dents and tea ching s cie nce? If a pplic able, are the faculty goo d rol e m od els for th e par ticip ants by na ture of th eir s ci entific ac com pl is hm e nts ? If the pr oject is c ollab orati ve or m ulti-PD/PI, d o the inve s tiga tors have

com plem e ntary and integ rated expe rtis e ; are thei r lea ders h ip ap proac h, go verna nce a nd or ganization al s tr uctur e app ropri ate for th e pro ject? Does the Advis ory C om m ittee i nclud e ind ividu als a nd ca reers outs ide of ac adem i c org aniza tions ?

Innovation

Tak ing i nto c ons id erati on th e nature o f the prop os ed res ea rch e ducation p rogra m , do es th e app lican t m ak e a s trong cas e for this progr am effecti vely reach ing a n aud ience in n eed o f the prog ram ’s

offering s ? Wh ere a pprop riate , is the p ropos ed pr ogram deve lopin g or utili zing innovative appr oache s and late s t be s t pr actic es to im pr ove the kn owled ge an d/or s kill s of the i ntend ed au dienc e? D oes the pro gram clear ly pr opos e to g o beyond the tr aditi onal train ing a ctivi ties exper ience d by gradu ate s tuden ts and pos tdocto ral s cientis ts ? Does the appli cant clear ly di s ting uis h what is no vel i n thi s BES T pro gram ?

Approach

Doe s the prop os ed progr am cl early s tate its goal s and obje ctive s , in cludi ng th e edu catio nal l evel of th e aud ience to b e rea ched, the conte nt to be c onveyed, a nd th e intended outc om e? Is there evide nce that the prog ram i s bas ed on a s o und r ation ale, as we ll as s oun d edu catio nal c oncep ts an d pri ncipl es ? If the prop os ed progr am wi ll re cruit participa nts , are the pl anned recr uitm e nt, r etention, and follow -up ( if app licab le) a ctivi ties adequ ate to ens ure a high ly qu alifi ed pa rtici pant pool?

Is the p lan for evaluation s ound and i s it likel y to provi de in form a tion on th e effectivenes s of the pr ogram . Wil l the prop os ed evalu ation plan provide i nform ation that will be u s eful for im pro vem en ts in the tim in g

or natur e of the p ropos ed ac tivities ? Does the e valua tion plan inclu de th e data ele m ents outl ined in th is FOA incl uding but not l im ite d to: trai nee c areer choi ces , train ee s a tis fa ction with care er tr ainin g and job pla cem en t, fa culty atti tudes towa rd ca reer plans of traine es , i ns titution al s u pport of n ew tr ainin g, cha nges in in s titu tiona l pol icies and/or ch anges in m entor ing p olici es , e tc. Is the dis s em ina tion plan ade quate ly de taile d? Is ther e a r obus t plan for facul ty bu y-in for the BE ST pr ogram , and will the

pro pos ed eval uatio n pla n reveal w hethe r the prop os ed level of faculty buy-in w as ac hieve d? If the pro gram s tarts with a s ubs et of p artic ipants , is ther e a p lan for in creas ing the s i ze of the progr am to ach ieve acces s ibil ity to all thos e at the i ns titution who wis h to pa rtici pate? Is there a pla n (or tim e line) pro vided that will ens u re th at th e tim e to degre e, or pos tdocto ral tenure will not be ad vers e ly affecte d by the BEST prog ram a ctivi ties ? Is there an ap propr iate plan for d is s em inati on of s ucc es s fu l and

uns ucces s ful practices ?

Environment

Wil l the s cie ntifi c and educ ation al en viron m ent of th e pro pos ed prog ram c ontri bute to its intended goa ls ? Is the re a plan to ta ke ad vanta ge of this envi ronm e nt to enha nce the ed ucati onal value of the pro gram ? Is there tang ible evide nce o f both s ho rt-te rm an d lon g-ter m ins titutional com m itm en t? Is the re evidenc e tha t the facu lty h ave s uffic ient ins ti tutio nal s uppor t to create a s ound educa tiona l environm ent for th e par ticip ants ? Whe re ap propr iate, is there evide nce o f col labor ation and buy-i n am o ng pa rtici patin g pro gram s , dep artm e nts , and i ns titution s ? If partners h ips a re in clude d in the B EST pro gram plan, are they appro priate and will they provide n ovel exper ience s ? (N ote: partn ers hi ps ar e not req uired but are s trong ly en coura ged a s app ropri ate.) Are the p artne r environm ents well des cr ibed, s up porti ve an d lik ely to con tribu te to the progr am go als ? Is there evide nce o f the prop os ed exter nal par tners ’ wil lingn es s to col labor ate a nd pa rtici pate?

Additional Review Criteria

As appli cable for the p rojec t pro pos ed , reviewer s wil l eva luate the follo wing additional item s whi le determ in ing s cientific and techni cal m erit, and in pr ovidi ng an over all i m pact s cor e, bu t wil l not give s epa rate s co res for th es e i tem s .

Protections for Human S ubjects

Gen erall y not appl icabl e. Re viewe rs s h ould bring any conce rns to the atte ntion of the Sc ienti fic R eview

Officer

Inclusion of Women, Minorities, and Children

Gen erall y not appl icabl e. Re viewe rs s h ould bring any conce rns to the atte ntion of the Sc ienti fic R eview

Officer.

Vertebrate Animals

Gen erall y not appl icabl e. Re viewe rs s h ould bring any conce rns to the atte ntion of the Sc ienti fic R eview

Officer.

Biohazards

Gen erall y not appl icabl e. Re viewe rs s h ould bring any conce rns to the atte ntion of the Sc ienti fic R eview

Officer.

Resubmissions

Not Appl icabl e

Renewals

Not Appl icabl e Revisions Not Appl icabl e

Additional Review Considerations

As appli cable for the p rojec t pro pos ed , reviewer s wil l con s ider each of the fo llowi ng item s , but w ill n ot gi ve s co res for th es e i tem s , and s houl d not cons ider them in pr ovidi ng an over all i m pact s cor e.

Recruitment & Retention Plan to Enhance Diversity

Pee r reviewer s wil l s ep arate ly evaluate the recr uitm e nt an d retentio n pla n to enhan ce di vers i ty after the ove rall s core has been deter m ined . Reviewer s wil l exa m ine the s trate gies to be us ed in the re cruitm ent and rete ntion of i ndivi duals from unde rrepr es ented gr oups . The revie w pan el’s evalu ation will be inc luded in the s u m m ary s tatem ent. Pla ns wi ll be rate d as acceptable or unacce ptable, an d the

s um m ary s tate m ent will provi de th e con s ens u s of the r eview com m ittee . Training in the Responsible Conduct of Research Not Appl icabl e

Applications from Foreign Organizations

Not Appl icabl e

Select A gent Research

Gen erall y not appl icabl e. Re viewe rs s h ould bring any conce rns to the atte ntion of the Sc ienti fic R eview

Officer.

Resource Sharing Plans

Reviewer s wil l com m ent on wh ether the follo wing Res ou rce S harin g Pla ns , o r the rati onale for not s ha ring the follow ing types of re s ourc es , a re re as ona ble: 1) Da ta Sh aring Plan; 2) Shari ng Mo del Org anis m s; an d 3) Genom e Wid e As s ociation S tudie s (GWAS). If s u pport for devel opm en t, m ai ntena nce, or en hance m ent of s o ftwar e is reque s ted in th e app lication, the r eview ers w ill c om m en t on the p ropos ed s o ftwar e dis s em in ation plan .

Budget and Period of Support

Reviewer s wil l con s ider whether the bu dget and the re ques ted pe riod of s u pport are fully jus tified and rea s onab le in rela tion to th e pro pos ed res e arch.

2. Revie w and Sele ction Process

App lications will be evaluated fo r s ci entific an d tec hnica l m er it by (an) appr opria te Sc ienti fic R eview Grou p(s ) con vened by the Ce nter for S cientific Revie w, in acco rdanc e with NIH peer revi ew po licy and p roced ures , us i ng th e s ta ted r eview criteria . As s i gnm en t to a Sci entific Re view Group will be s hown in th e eRA

Com m ons .

As part of th e s ci entific pe er re view, all appli catio ns :

May unde rgo a s ele ction proc es s i n whi ch on ly th os e a pplic ation s dee m ed to have the high es t s ci entific an d tec hnica l m er it (g enera lly the to p hal f of appli catio ns un der r eview ) wil l be dis cu s s ed and as s i gned an overall im pa ct s c ore.

Wil l rec eive a wri tten criti que.

App eals of in itial peer revi ew wi ll no t be accep ted for ap plica tions s ubm itted in r es pon s e to this FOA. App lications will be as s igne d to the a pprop riate NIH Ins ti tute or Ce nter. Appl icati ons w ill c om pete for

ava ilabl e fun ds wi th al l oth er re com m e nded appli catio ns s u bm itted in res p ons e to th is FOA. Fo llowi ng in itial pee r review, recom m ende d app lications will recei ve a s econ d level of revi ew by the Natio nal Advis o ry De ntal and Cran iofac ial R es ear ch Co uncil . The foll owing will be c ons id ered in m a king fundi ng de cis io ns :

Sci entific an d tec hnica l m er it of the propo s ed p rojec t as deter m ined by s cientific peer revie w. Ava ilabi lity of fu nds .

Rel evanc e of the p ropos ed pr oject to p rogra m pri oriti es .

3. Anticipate d Announce ment and Award Dates

After th e pee r review o f the appl icati on is com p leted , the PD/P I wil l be able to ac ces s his o r her Sum m ary

Sta tem en t (wr itten critique) via the e RA Co m m ons .

Inform ation r egard ing the di s pos i tion of ap plica tions is a vaila ble i n the NIH Grants Pol icy S tatem ent.

Section VI. Award Administration Information

1. Award Notices

If the a pplic ation is u nder cons i deration for fu nding , NIH will requ es t "jus t- in-ti m e" i nform ation from the app lican t as des cr ibed in th e NIH Gran ts Po licy State m ent.

A form al noti fication i n the form of a Noti ce of Awar d (No A) wi ll be provided to th e app lican t org aniza tion for s uc ces s ful ap plica tions . The NoA s igne d by the g rants m ana gem en t officer is th e authorizing d ocum e nt an d wil l be s ent via e m ail to th e gra ntee’ s bus ines s offi cial.

Awa rdees m us t com p ly wi th an y fun ding res tr ictio ns de s crib ed in Section IV.5. Fundi ng Re s tric tions . Sel ectio n of an ap plica tion for a ward is no t an autho rization to beg in pe rform ance. Any cos ts incu rred befor e rec eipt of th e NoA are at th e rec ipien t's r is k. Thes e cos ts m ay be r eim bu rs ed only to th e extent c ons id ered all owabl e pre -awar d cos ts .

Any appl icati on aw arded in r es pon s e to this FOA will be s u bject to the DU NS, S AM Re gis tr ation , and Tra ns par ency Act r equir em ents as noted on the Aw ard C onditions and Inform ation for NIH Gra nts http://grants .nih .gov/grants /pol icy/a wardc onditions .htm w ebs ite.

2. Administrative and National Policy Requirements

All NIH grant and coope rative agr eem en t awa rds i nclud e the NIH Grants Pol icy S tatem ent a s par t of the N oA. For thes e ter m s of awar d, s e e the NIH Grants Pol icy S tatem ent P art II: Te rm s a nd Co nditi ons o f NIH Gran t Awa rds , Subpa rt A: Gene ral and P art II: Te rm s a nd Co nditi ons o f NIH Gran t Awa rds , Subpa rt B: Term s and

Con ditio ns fo r Spe cific Type s of Grants , Gr antee s , an d Activiti es . More i nform ation is p rovid ed at Awar d

Con ditio ns an d Inform ation for NIH Gra nts .

3. Reporting

The Non- Com pe ting Conti nuati on Gr ant P rogre s s Re port (PHS 2590 or RP PR) a nd fi nanci al s tatem e nts a s des cribe d in the N IH Gr ants Polic y Sta tem en t are requ ired annua lly. Conti nuati on s u pport will not be pro vided unti l the requ ired form s are s ubm i tted and a ccepted. P rogra m s th at in volve participa nts s hould rep ort o n edu catio n in the r es pon s ible cond uct o f res earch and com pl ete a Trai ning Diver s ity Repor t, in acc ordan ce wi th th e PHS 2590 Addi tiona l Ins tructions for P repar ing a Prog res s Repor t for an Ins titution al Res earch Trai ning Grant, Inc ludin g Ruth L. Kirs c hs tei n National Res e arch Servi ce Aw ards .

The Fede ral Fundin g Acc ounta bility and Tran s pare ncy Act of 2006 (Tra ns par ency Act), incl udes a

req uirem ent for aw ardee s of Feder al gr ants to re port infor m atio n abo ut fi rs t-tier s ubawa rds a nd executi ve com pens a tion under Fede ral a s s is tance award s is s ued i n FY2 011 o r later. All a warde es of appl icabl e NIH gra nts a nd co opera tive agree m ents are requi red to rep ort to the Fede ral S ubawa rd Re porti ng Sys tem (FS RS) a vaila ble a t www .fs rs .gov on al l s ub award s ove r $25 ,000. See the NIH Grants Poli cy Statem e nt fo r add ition al in form a tion on th is re porti ng re quire m ent.

Fai lure by th e gra ntee ins ti tutio n to s ubm i t req uired form s in a tim ely, com pl ete, and a ccura te m a nner m ay res ult i n an expen ditur e dis allow ance or a delay in a ny co ntinu ation fund ing for th e awa rd.

Other Reporting Requirements

A final progr es s r eport and the e xpend iture data portion o f the Fede ral Financ ial R eport are requi red for clo s eout of a n awa rd as des c ribed in the NI H Gra nts P olicy Statem ent.

4. Evaluation

In carrying o ut its s te wards hip o f hum an re s ourc e-rel ated progr am s , the N IH or its Ins ti tutes and Cente rs wi ll per iodic ally evalu ate their BEST progr am s , em plo ying the m eas ur es id entified b elow. In as s es s ing the effectivenes s of i ts re s earc h edu catio n inves tm e nts , NIH m ay re ques t info rm ati on fr om da tabas es , P D/PIs , and from participa nts them s e lves . Whe re ne ces s a ry, P D/PIs and parti cipan ts m a y be conta cted after the

com pleti on of a re s earc h edu catio n exp erien ce fo r per iodic upda tes o n par ticip ants ’ s ubs equen t edu catio nal or em plo ym ent his tory a nd pr ofes s ional acti vitie s .

^{Section VII. Agency Contacts}

We encou rage inqui ries conce rning this fund ing o pportunity and welco m e th e opp ortun ity to ans wer que s tion s fro m potentia l app lican ts .

Application S ubmission Contacts

eRA Com m ons H elp D es k ( Ques tions regar ding eRA C om m on s reg is tra tion, s ubm ittin g and trac king an app lication, docum entin g s ys tem p roble m s th at th reate n s ub m is s i on by the due d ate, pos t s ubm i s s ion is s ues )Teleph one: 301-4 02-74 69 or 866- 504-9 552 ( Toll Free)

Web tick eting s ys tem : h ttps ://pub lic.e ra.ni h.gov/com m ons he lp

TTY: 301 -451- 5939

Em a il: c om m on s @od.nih.g ov

Gra nts .g ov Cu s tom e r Sup port (Ques tions rega rding Gran ts .go v reg is tra tion and s ubm is s ion, down loadi ng for m s an d app lication p ackag es )

Con tact Cente r Tel ephon e: 80 0-518 -4726

Web tick eting s ys tem : h ttps ://gra nts -p ortal .ps c.gov/C ontac tUs .a s px

_{Em a il: s uppor t@gra nts .g ov}

Gra nts In fo (Ques ti ons r egard ing a pplic ation ins tructi ons a nd pr oces s , fin ding NIH g rant res ou rces ) Tel ephon e 301 -435- 0714

TTY: 301 -451- 5936

_{Em a il: Grants Info@ nih.g ov}

Scientific/Research Contact(s)

Dr. Patr icia Labos ky

Divis ion of P rogra m Coo rdina tion, Plan ning and S trate gic Initia tives

Office o f the Dire ctor, NIH Tel ephon e: 30 1-594 -4863

_{Em a il: l abos k ypa@o d.nih .gov}

Peer Review Contact(s)

Lar ry Bo erboo m , Ph .D.

Cen ter for Sc ienti fic R eview (CSR ) Tel ephon e: 30 1-435 -8367

_{Em a il: b oerbo ol@m a il.ni h.gov}

Financial/Grants Management Contact(s)

Ded e Rutberg, MBA

National Ins titute of D ental and Crani ofaci al Re s earc h (NIDCR) Tel ephon e: 30 1-594 -4798

_{Em a il: r utber gd@m a il.ni h.gov}

Mic hael Mors e

Divis ion of P rogra m Coo rdina tion Plann ing a nd Strateg ic In itiatives

Office o f the Dire ctor, NIH Tel ephon e: 30 1-435 -5446

Em a il: m ors em @od.n ih.go v

Section VIII. Other Information

Rec ently is s u ed tr ans -N IH po licy notic es m a y affect your a pplic ation s ubm is s io n. A full lis t of po licy notic es pub lis he d by NIH i s pro vided in the NI H Gui de fo r Gra nts a nd Co ntrac ts. All aw ards are s ubjec t to the term s and cond ition s , co s t pr incip les , and o ther cons i derations des cr ibed in th e NIH Gran ts Po licy State m ent.

Authority and Regulations

Awa rds a re m a de un der the au thori zatio n of Secti ons 3 01 an d 405 of the Pu blic Health Ser vice Act a s am e nded (42 U SC 24 1 and 284) and under Fede ral R egula tions 42 C FR Pa rt 52 and 45 CFR Par ts 74 and

92.

Wee kly TOC fo r thi s Ann ounce m ent

_{NIH Fund ing Opportuniti es an d Notices}

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Department of Healt h and Human Services (HHS)

2/19/2014 ^{RFA-RM-13-019: NIH Directcrs Bianedical Research Wcrkfcrce lnnovatioo Award: Broadening Elq:Jeriences in Scientific Training (BEST) (DP7)}

NIH... Turning Discovery Into Health

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