AMAP Test for Organic Pollutants in Human Serum

Att9d AMAP 2014-01 - English.pdf

Biomonitoring of Great Lakes Populations Program II

AMAP Test for Organic Pollutants in Human Serum

OMB: 0923-0052

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AMAP RING TEST FOR PERSISTENT ORGANIC
POLLUTANTS IN HUMAN SERUM
(AMAP)

Scope of accreditation:

REPORT FOR ROUND:

2014-01

PTMS SHIPPING DATE:

2014-01-27

DATE OF PUBLICATION:

2014-04-11

The concentrations of PCB IUPAC # 138 in material AM-S-W1403,
PCB IUPAC # 153 in material AM-S-W1402, p,p’-DDE in material
AM-S-W1401, PBDE IUPAC 153 in material AM-S-W1401, PFHxA in material
AM-S-Y1402 and PFHxS in material AM-S-Y1403 exceed the level of our
scope of accreditation.
Total cholesterol, total lipids and triglycerides are not included in our
scope of accreditation.

Centre de toxicologie/INSPQ

945, Ave Wolfe
Québec, QC
Canada, G1V 5B3

Phone: (418) 650-5115 Ext. 5254
Fax : (418) 654-2148
E-mail : ctq@inspq.qc.ca
http://www.inspq.qc.ca/ctq

AMAP Ring Test for Persistent Organic
Pollutants in Human Serum

TABLE OF CONTENTS
INTRODUCTION

1

SERUM
Dieldrin

2

ß-HCH

5

Heptachlor

8

Heptachlor epoxide

11

Hexachlorobenzene

14

Oxychlordane

17

p,p’-DDE

20

p,p’-DDT

23

PBDE IUPAC # 28

26

PBDE IUPAC # 47

29

PBDE IUPAC # 99

32

PBDE IUPAC # 100

35

PBDE IUPAC # 153

38

PBDE IUPAC # 154

41

PBDE IUPAC # 183

44

PBDE IUPAC # 209

47

PCB IUPAC # 28

50

PCB IUPAC # 74

53

PCB IUPAC # 99

56

PCB IUPAC # 105

59

PCB IUPAC # 118

62

PCB IUPAC # 138

65

PCB IUPAC # 153

68

PCB IUPAC # 170

71

PCB IUPAC # 180

74

Centre de toxicologie/INSPQ

945, Ave Wolfe
Quebec, QC
Canada, G1V 5B3

Phone: (418) 650-5115 Ext. 5254
Fax : (418) 654-2148
E-mail : ctq@inspq.qc.ca
http://www.inspq.qc.a/ctq

AMAP Ring Test for Persistent Organic
Pollutants in Human Serum

TABLE OF CONTENTS
PFHxA

77

PFHxS

80

PFNA

83

PFOA

86

PFOS

89

PFUdA

92

Total Cholesterol

95

Total lipids

98

Toxaphene Parlar # 26

101

Toxaphene Parlar # 50

104

trans-nonachlor

107

Triglycerides

110

ASSIGNED VALUES

113

GROUPING OF ANALYTICAL METHODS FOR STATISTICS

115

Centre de toxicologie/INSPQ

945, Ave Wolfe
Quebec, QC
Canada, G1V 5B3

Phone: (418) 650-5115 Ext. 5254
Fax : (418) 654-2148
E-mail : ctq@inspq.qc.ca
http://www.inspq.qc.a/ctq

AMAP Ring Test for Persistent Organic
Pollutants in Human Serum

INTRODUCTION
Dear AMAP participants:
This report includes the results and performance evaluations of round 2014-01.
Participating laboratories are identified only by their unique subscription number.
Identity of participants will be kept strictly confidential by the AMAP organizer.
For this PT exercise, all analytes meet the homogeneity criteria as per ISO/CEI 17043
and 13528 guidelines with the exception of heptachlor in materials AM-S-W1401,
AM-S-W1402 and AM-S-W1403. A note concerning the homogeneity of heptachlor has
been included in the corresponding section.
A study had been previously performed to demonstrate that all the analytes are stable
for the duration of the PT exercise and meet the stability criteria according to ISO/CEI
17043 and 13528 guidelines.
Please note that the appendices containing statistical approaches are no longer
included in the reports. You will find them within the “Participant’s Guide”.
We are available to assist you at any time. If you have any questions or concerns
regarding our program, do not hesitate to contact us. Your comments help us enhance
the quality of our schemes.
Best regards,

David Bisson, M.Sc. Chemist
Programs Coordinator
External Quality Assessment Schemes and Reference Materials
Centre de toxicologie du Québec / INSPQ
Tel.: (418) 650-5115, extension 4649
E-mail: david.bisson@inspq.qc.ca
Web Site: www.inspq.qc.ca/CTQ/paqe

Centre de toxicologie/INSPQ

945, Ave Wolfe
Québec, QC
Canada, G1V 5B3

Phone: (418) 650-5115 Ext. 5254
Fax : (418) 654-2148
E-mail : ctq@inspq.qc.ca
http://www.inspq.qc.ca/ctq
1

Individual results
Serum Dieldrin (µg/L)
Round #2014-01

Participant

AM-S-W1401

z’-score

AM-S-W1402

z’-score

AM-S-W1403

z’-score

Method

754

1.40

0.07

0.238

4.23

1.28

0.00

GC

1042

1.38

0.00

0.0965

-0.30

1.23

-0.20

GC-MS CI

2446

1.59

0.71

0.0700

-1.15

1.34

0.23

GC-MS EI

4336

1.13

-0.84

LL

---

1.24

-1.30

4.34

-1.71

ND

8559

59.8

-0.70

1.52

0.05

5.59

-0.07

ND

8916

60.8

-0.59

1.33

-0.87

5.18

-0.61

GC

9301

79.7

1.42

1.88

1.79

6.43

1.04

GC-MS EI

Assigned value

Standard
uncertainty

σ pt

Acceptable range

K-S (Lilliefors)

Species

AM-S-W1401

66.4*

3.33

8.77

47.6 - 85.2

Accepted

---

AM-S-W1402

1.51

0.0545

0.199

1.10 - 1.92

Accepted

---

AM-S-W1403

5.64

0.159

0.745

4.12 - 7.16

Accepted

---

The assigned value is outside the concentration range of our scope of accreditation.

Centre de toxicologie du Québec/INSPQ - External quality assessment schemes

20

Statistics
Serum p,p'-DDE (µg/L)
All methods

AM-S-W1401

AM-S-W1402

16

17

17

Robust mean Algo A

66.4

1.51

5.64

Robust STDev

10.7

0.180

0.523

Median

65.6

1.50

5.59

STDev from MAD

9.62

0.163

0.534

Arithmetic mean

66.2

1.52

5.62

STDev

10.5

0.199

0.559

CV or Variability

16.1%

11.9%

9.3%

AM-S-W1401

AM-S-W1402

AM-S-W1403

3

3

3

Robust mean Algo A

74.6

1.58

5.68

Robust STDev

1.87

0.150

0.526

Median

75.0

1.61

5.78

STDev from MAD

1.48

0.119

0.460

Arithmetic mean

70.6

1.54

5.68

STDev

8.48

0.190

0.464

CV or Variability

2.5%

9.5%

9.3%

AM-S-W1401

AM-S-W1402

AM-S-W1403

N

GC
N

GC-MS EI
N

AM-S-W1403

4

4

4

Robust mean Algo A

79.4

1.62

6.14

Robust STDev

4.08

0.175

0.588

Median

79.6

1.60

6.22

STDev from MAD

3.13

0.145

0.489

Arithmetic mean

73.6

1.64

6.13

STDev

14.9

0.183

0.541

CV or Variability

5.1%

10.8%

9.6%

When fewer than 20 results were considered for statistical treatment of all or a sub-sample of
results, the accuracy of statistical data may be questionable.

Centre de toxicologie du Québec/INSPQ - External quality assessment schemes

21

Distribution
Serum p,p'-DDE (µg/L)

Centre de toxicologie du Québec/INSPQ - External quality assessment schemes

22

Individual results
Serum p,p'-DDT (µg/L)
Round #2014-01

Participant

AM-S-W1401

z’-score

AM-S-W1402

z’-score

AM-S-W1403

z’-score

748

0.396

0.24

0.604

-0.21

0.861

0.34

Method
ND

754

0.389

0.18

0.588

-0.30

0.775

-0.10

GC

1003

0.361

-0.03

0.669

0.17

0.802

0.04

GC-MS-MS

1042

0.349

-0.12

0.675

0.20

0.822

0.14

GC-MS CI

2446

0.290

-0.57

0.540

-0.58

0.680

-0.58

GC-MS EI

2968

0.342

-0.18

0.693

0.31

0.825

0.16

GC-MS EI

4336

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AuthorDavid Bisson
File Modified2014-04-11
File Created2014-04-11

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