Att1 Examples of potential methodological studies to inform the PATH Study

PATH Study Generic Clearance for Methodological Studies (NIDA)

Attachment 1
Examples of Potential Methodological Studies to
Inform the PATH Study
January 29, 2013

Examples of potential methodological studies to inform the PATH Study
Intended Study
Outcome(s)
Brief, cost-efficient,
psychometrically sound
mode of data collection.at
follow-up

Example
Web-ACASI Comparison

Background/Purpose
To examine the
equivalence of Web and
ACASI data

Study Design
At follow-up, PATH Study
respondents would be
randomly assigned to
answer the same questions
either via the Web or
ACASI

Collection of
biospecimens via the mail
and in-person

To examine the
equivalence of urine
specimens gathered via the
mail and in-person

At follow-up, PATH Study
respondents who provided
a urine specimen at
baseline would be
randomly assigned to
provide a urine specimen
either via the mail or inperson

Brief, cost-efficient,
psychometrically sound
procedures for gathering
urine specimens at followup

Reliability of PATH Study
Questionnaires

To examine the test-retest
reliability of PATH Study
questionnaires

PATH Study respondents
would be reinterviewed
and asked the same set of
questions within 10-14
days of an initial interview

Brief, cost-efficient,
psychometrically sound
direct assessment of the
reliability of data gathered
with the PATH Study
questionnaires

Comparison of self-reports
with CO or Cotinine

To examine the validity of
self-reported tobacco use
among PATH Study
respondents

PATH Study respondents
would be asked to provide
a urine sample or breathe
into a mechanism to obtain
biomarkers of tobacco use

Brief, cost-efficient,
psychometrically sound
assessment of the validity
of data gathered with the
PATH Study
questionnaires