Publications 2006-2007

OSMB REPORT DECEMBER 2007:
FRAMINGHAM HEART STUDY (GENERAL AND GENETIC)
JOURNAL ARTICLES FROM 09-30-06 TO 09-30-07
[115 PUBLICATIONS AVAILABLE ON CD AND 7 IN PRESS ARTICLES PENDING]

Abdel-Qadir HM, Lee DS: The contribution of familial and heritable risks in heart failure.
Curr Opin Cardiol 2007; 22(3):214-219 PM:17413278.
Benjamin EJ, Dupuis J, Larson MG, Lunetta KL, Booth SL, Govindaraju DR, Kathiresan
S, Keaney JF, Jr., Keyes MJ, Lin JP, Meigs JB, Robins SJ, Rong J, Schnabel R, Vita JA,
Wang TJ, Wilson PW, Wolf PA, Vasan RS: Genome-wide association with select
biomarker traits in the Framingham Heart Study. BMC Med Genet 2007; 8 Suppl 1:S11
PM:17903293.
Berry SD, Samelson EJ, Hannan MT, McLean RR, Lu M, Cupples LA, Shaffer ML,
Beiser AL, Kelly-Hayes M, Kiel DP: Second hip fracture in older men and women: the
Framingham Study. Arch Intern Med 2007; 167(18):1971-1976 PM:17923597.
Brindle P, May M, Gill P, Cappuccio F, D'Agostino R, Sr., Fischbacher C, Ebrahim S:
Primary prevention of cardiovascular disease: a web-based risk score for seven British
black and minority ethnic groups. Heart 2006; 92(11):1595-1602 PM:16762981.
Carandang R, Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Kannel WB, Wolf PA:
Trends in incidence, lifetime risk, severity, and 30-day mortality of stroke over the past
50 years. JAMA 2006; 296(24):2939-2946 PM:17190894.
Carandang R, Wolf PA: Trends in stroke over the past 50 years: the Framingham Study.
Cardiology Review 2007; 24(8):23-25 .
Christakis NA, Fowler JH: The spread of obesity in a large social network over 32 years.
N Engl J Med 2007; 357(4):370-379 PM:17652652.
Cobain MR, Pencina MJ, D'Agostino RB, Sr., Vasan RS: Lifetime risk for developing
dyslipidemia: the Framingham Offspring Study. Am J Med 2007; 120(7):623-630
PM:17602937.
Corella D, Lai CQ, Demissie S, Cupples LA, Manning AK, Tucker KL, Ordovas JM:
APOA5 gene variation modulates the effects of dietary fat intake on body mass index
and obesity risk in the Framingham Heart Study. J Mol Med 2007; 85(2):119-128
PM:17211608.
Cupples LA, Arruda HT, Benjamin EJ, D'Agostino RB, Sr., Demissie S, DeStefano AL,
Dupuis J, Falls KM, Fox CS, Gottlieb DJ, Govindaraju DR, Guo CY, Heard-Costa NL,
Hwang SJ, Kathiresan S, Kiel DP, Laramie JM, Larson MG, Levy D, Liu CY, Lunetta KL,
Mailman MD, Manning AK, Meigs JB, Murabito JM, Newton-Cheh C, O'connor GT,
O'Donnell CJ, Pandey M, Seshadri S, Vasan RS, Wang ZY, Wilk JB, Wolf PA, Yang Q,
Atwood LD: The Framingham Heart Study 100K SNP genome-wide association study
resource: overview of 17 phenotype working group reports. BMC Med Genet 2007; 8
Suppl 1:S1 PM:17903291.

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Demissie S, Dupuis J, Cupples LA, Beck TJ, Kiel DP, Karasik D: Proximal hip geometry
is linked to several chromosomal regions: genome-wide linkage results from the
Framingham Osteoporosis Study. Bone 2007; 40(3):743-750 PM:17079199.
Dhingra R, Sullivan L, Jacques PF, Wang TJ, Fox CS, Meigs JB, D'Agostino RB,
Gaziano JM, Vasan RS: Soft drink consumption and risk of developing cardiometabolic
risk factors and the metabolic syndrome in middle-aged adults in the community.
Circulation 2007; 116(5):480-488 PM:17646581.
Dhingra R, Sullivan LM, Fox CS, Wang TJ, D'Agostino RB, Sr., Gaziano JM, Vasan RS:
Relations of serum phosphorus and calcium levels to the incidence of cardiovascular
disease in the community. Arch Intern Med 2007; 167(9):879-885 PM:17502528.
Djousse L, Karamohamed S, Herbert AG, D'Agostino RB, Cupples LA, Ellison RC:
Fucosyltransferase 3 polymorphism and atherothrombotic disease in the Framingham
Offspring Study. Am Heart J 2007; 153(4):636-639 PM:17383304.
Eaker ED, Sullivan LM, Kelly-Hayes M, D'Agostino RB, Sr., Benjamin EJ: Marital status,
marital strain, and risk of coronary heart disease or total mortality: the Framingham
Offspring Study. Psychosom Med 2007; 69(6):509-513 PM:17634565.
Elias MF, Sullivan LM, Elias PK, D'Agostino RB, Sr., Wolf PA, Seshadri S, Au R,
Benjamin EJ, Vasan RS: Left ventricular mass, blood pressure, and lowered cognitive
performance in the Framingham offspring. Hypertension 2007; 49(3):439-445
PM:17224472.
Ellison RC, Zhang Y, Hopkins PN, Knox S, Djousse L, Carr JJ: Is alcohol consumption
associated with calcified atherosclerotic plaque in the coronary arteries and aorta? Am
Heart J 2006; 152(1):177-182 PM:16824853.
Felson DT, Niu J, Clancy M, Sack B, Aliabadi P, Zhang Y: Effect of recreational physical
activities on the development of knee osteoarthritis in older adults of different weights:
the Framingham Study. Arthritis Rheum 2007; 57(1):6-12 PM:17266077.
Felson DT, Niu J, Clancy M, Aliabadi P, Sack B, Guermazi A, Hunter DJ, Amin S,
Rogers G, Booth SL: Low levels of vitamin D and worsening of knee osteoarthritis:
results of two longitudinal studies. Arthritis Rheum 2007; 56(1):129-136 PM:17195215.
Felson DT, Niu J, McClennan C, Sack B, Aliabadi P, Hunter DJ, Guermazi A, Englund
M: Knee buckling: prevalence, risk factors, and associated limitations in function. Ann
Intern Med 2007; 147(8):534-540 PM:17938391.
Fogli-Cawley JJ, Dwyer JT, Saltzman E, McCullough ML, Troy LM, Jacques PF: The
2005 Dietary Guidelines for Americans Adherence Index: development and application.
J Nutr 2006; 136(11):2908-2915 PM:17056821.
Fogli-Cawley JJ, Dwyer JT, Saltzman E, McCullough ML, Troy LM, Meigs JB, Jacques
PF: The 2005 Dietary Guidelines for Americans and risk of the metabolic syndrome. Am
J Clin Nutr 2007; 86(4):1193-1201 PM:17921402.

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Fogli-Cawley JJ, Dwyer JT, Saltzman E, McCullough ML, Troy LM, Meigs JB, Jacques
PF: The 2005 Dietary Guidelines for Americans and insulin resistance in the
Framingham Offspring Cohort. Diabetes Care 2007; 30(4):817-822 PM:17259479.
Foster MC, Hwang SJ, Larson MG, Parikh NI, Meigs JB, Vasan RS, Wang TJ, Levy D,
Fox CS: Cross-classification of microalbuminuria and reduced glomerular filtration rate:
associations between cardiovascular disease risk factors and clinical outcomes. Arch
Intern Med 2007; 167(13):1386-1392 PM:17620532.
Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY, Vasan RS,
Murabito JM, Meigs JB, Cupples LA, D'Agostino RB, Sr., O'Donnell CJ: Abdominal
visceral and subcutaneous adipose tissue compartments: association with metabolic risk
factors in the Framingham Heart Study. Circulation 2007; 116(1):39-48 PM:17576866.
Fox CS, Coady S, Sorlie PD, D'Agostino RB, Sr., Pencina MJ, Vasan RS, Meigs JB,
Levy D, Savage PJ: Increasing cardiovascular disease burden due to diabetes mellitus:
the Framingham Heart Study. Circulation 2007; 115(12):1544-1550 PM:17353438.
Fox CS, Heard-Costa N, Cupples LA, Dupuis J, Vasan RS, Atwood LD: Genome-wide
association to body mass index and waist circumference: the Framingham Heart Study
100K project. BMC Med Genet 2007; 8 Suppl 1:S18 PM:17903300.
Gottlieb DJ, O'connor GT, Wilk JB: Genome-wide association of sleep and circadian
phenotypes. BMC Med Genet 2007; 8 Suppl 1:S9 PM:17903308.
Gross KD, Niu J, Zhang YQ, Felson DT, McLennan C, Hannan MT, Holt KG, Hunter DJ:
Varus foot alignment and hip conditions in older adults. Arthritis Rheum 2007;
56(9):2993-2998 PM:17763430.
Guo CY, Lunetta KL, DeStefano AL, Ordovas JM, Cupples LA: Informative-transmission
disequilibrium test (i-TDT): combined linkage and association mapping that includes
unaffected offspring as well as affected offspring. Genet Epidemiol 2007; 31(2):115-133
PM:17123304.
Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, Illig T, Wichmann HE, Meitinger
T, Hunter D, Hu FB, Colditz G, Hinney A, Hebebrand J, Koberwitz K, Zhu X, Cooper R,
Ardlie K, Lyon H, Hirschhorn JN, Laird NM, Lenburg ME, Lange C, Christman MF: A
common genetic variant is associated with adult and childhood obesity. Science 2006;
312(5771):279-283 PM:16614226.
Herbert A, Lenburg ME, Ulrich D, Gerry NP, Schlauch K, Christman MF: Open-access
database of candidate associations from a genome-wide SNP scan of the Framingham
Heart Study. Nat Genet 2007; 39(2):135-136 PM:17262019.
Hunter DJ, Niu J, Felson DT, Harvey WF, Gross KD, McCree P, Aliabadi P, Sack B,
Zhang Y: Knee alignment does not predict incident osteoarthritis: the Framingham
osteoarthritis study. Arthritis Rheum 2007; 56(4):1212-1218 PM:17393450.
Hwang SJ, Yang Q, Meigs JB, Pearce EN, Fox CS: A genome-wide association for
kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study.
BMC Med Genet 2007; 8 Suppl 1:S10 PM:17903292.

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Ingelsson E, Sullivan LM, Fox CS, Murabito JM, Benjamin EJ, Polak JF, Meigs JB,
Keyes MJ, O'Donnell CJ, Wang TJ, D'Agostino RB, Wolf PA, Vasan RS: Burden and
prognostic importance of subclinical cardiovascular disease in overweight and obese
individuals. Circulation 2007; 116(4):375-384 PM:17620505.
Ingelsson E, Sullivan LM, Murabito JM, Fox CS, Benjamin EJ, Polak JF, Meigs JB,
Keyes MJ, O'Donnell CJ, Wang TJ, D'Agostino RB, Sr., Wolf PA, Vasan RS: Prevalence
and prognostic impact of subclinical cardiovascular disease in individuals with the
metabolic syndrome and diabetes. Diabetes 2007; 56(6):1718-1726 PM:17369522.
Ingelsson E, Larson MG, Fox CS, Yin X, Wang TJ, Lipinska I, Pou KM, Hoffmann U,
Benjamin EJ, Keaney JF, Jr., Vasan RS: Clinical correlates of circulating visfatin levels
in a community-based sample. Diabetes Care 2007; 30(5):1278-1280 PM:17261750.
Ingelsson E, Schaefer EJ, Contois JH, McNamara JR, Sullivan L, Keyes MJ, Pencina
MJ, Schoonmaker C, Wilson PW, D'Agostino RB, Vasan RS: Clinical utility of different
lipid measures for prediction of coronary heart disease in men and women. JAMA 2007;
298(7):776-785 PM:17699011.
Ingelsson E, Pencina MJ, Tofler GH, Benjamin EJ, Lanier KJ, Jacques PF, Fox CS,
Meigs JB, Levy D, Larson MG, Selhub J, D'Agostino RB, Sr., Wang TJ, Vasan RS:
Multimarker approach to evaluate the incidence of the metabolic syndrome and
longitudinal changes in metabolic risk factors: the Framingham Offspring Study.
Circulation 2007; 116(9):984-992 PM:17698726.
Ingelsson E, Larson MG, Vasan RS, O'Donnell CJ, Yin X, Hirschhorn JN, Newton-Cheh
C, Drake JA, Musone SL, Heard-Costa NL, Benjamin EJ, Levy D, Atwood LD, Wang TJ,
Kathiresan S: Heritability, linkage, and genetic associations of exercise treadmill test
responses. Circulation 2007; 115(23):2917-2924 PM:17548724.
Ioannidis JP, Ng MY, Sham PC, Zintzaras E, Lewis CM, Deng HW, Econs MJ, Karasik
D, Devoto M, Kammerer CM, Spector T, Andrew T, Cupples LA, Duncan EL, Foroud T,
Kiel DP, Koller D, Langdahl B, Mitchell BD, Peacock M, Recker R, Shen H, Sol-Church
K, Spotila LD, Uitterlinden AG, Wilson SG, Kung AW, Ralston SH: Meta-analysis of
genome-wide scans provides evidence for sex- and site-specific regulation of bone
mass. J Bone Miner Res 2007; 22(2):173-183 PM:17228994.
Jefferson AL, Massaro JM, Wolf PA, Seshadri S, Au R, Vasan RS, Larson MG, Meigs
JB, Keaney JF, Jr., Lipinska I, Kathiresan S, Benjamin EJ, Decarli C: Inflammatory
biomarkers are associated with total brain volume: the Framingham Heart Study.
Neurology 2007; 68(13):1032-1038 PM:17389308.
Kannel WB: Cardiovascular disease preventive measures for the older patient: an
epidemiologic perspective. Am J Geriatr Cardiol 2006; 15(6):382-388 PM:17086034.
Karasik D, Dupuis J, Cupples LA, Beck TJ, Mahaney MC, Havill LM, Kiel DP, Demissie
S: Bivariate linkage study of proximal hip geometry and body size indices: the
Framingham Study. Calcif Tissue Int 2007; 81(3):162-173 PM:17674073.
Kathiresan S, Larson MG, Keyes MJ, Polak JF, Wolf PA, D'Agostino RB, Jaffer FA,
Clouse ME, Levy D, Manning WJ, O'Donnell CJ: Assessment by cardiovascular

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magnetic resonance, electron beam computed tomography, and carotid ultrasonography
of the distribution of subclinical atherosclerosis across Framingham risk strata. Am J
Cardiol 2007; 99(3):310-314 PM:17261388.
Kathiresan S, Manning AK, Demissie S, D'Agostino RB, Surti A, Guiducci C, Gianniny L,
Burtt NP, Melander O, Orho-Melander M, Arnett DK, Peloso GM, Ordovas JM, Cupples
LA: A genome-wide association study for blood lipid phenotypes in the Framingham
Heart Study. BMC Med Genet 2007; 8 Suppl 1:S17 PM:17903299.
Kiel DP, Ferrari SL, Cupples LA, Karasik D, Manen D, Imamovic A, Herbert AG, Dupuis
J: Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus
modulates Wnt signaling and the relationship of physical activity with bone mineral
density in men. Bone 2007; 40(3):587-596 PM:17137849.
Kiel DP, Demissie S, Dupuis J, Lunetta KL, Murabito JM, Karasik D: Genome-wide
association with bone mass and geometry in the Framingham Heart Study. BMC Med
Genet 2007; 8 Suppl 1:S14 PM:17903296.
Larson MG, Atwood LD, Benjamin EJ, Cupples LA, D'Agostino RB, Sr., Fox CS,
Govindaraju DR, Guo CY, Heard-Costa NL, Hwang SJ, Murabito JM, Newton-Cheh C,
O'Donnell CJ, Seshadri S, Vasan RS, Wang TJ, Wolf PA, Levy D: Framingham Heart
Study 100K project: genome-wide associations for cardiovascular disease outcomes.
BMC Med Genet 2007; 8 Suppl 1:S5 PM:17903304.
Lee DS, Evans JC, Robins SJ, Wilson PW, Albano I, Fox CS, Wang TJ, Benjamin EJ,
D'Agostino RB, Vasan RS: Gamma glutamyl transferase and metabolic syndrome,
cardiovascular disease, and mortality risk: the Framingham Heart Study. Arterioscler
Thromb Vasc Biol 2007; 27(1):127-133 PM:17095717.
Lee DS, Massaro JM, Wang TJ, Kannel WB, Benjamin EJ, Kenchaiah S, Levy D,
D'Agostino RB, Sr., Vasan RS: Antecedent blood pressure, body mass index, and the
risk of incident heart failure in later life. Hypertension 2007; 50(5):869-876
PM:17893376.
Lessov-Schlaggar CN, Swan GE, Reed T, Wolf PA, Carmelli D: Longitudinal genetic
analysis of executive function in elderly men. Neurobiol Aging 2007; 28(11):1759-1768
PM:16965841.
Levy D: Hypertension from Framingham to ALLHAT: translating clinical trials into
practice. Cleve Clin J Med 2007; 74(9):672-678 PM:17879521.
Levy D, Hwang SJ, Kayalar A, Benjamin EJ, Vasan RS, Parise H, Larson MG, Wang TJ,
Selhub J, Jacques PF, Vita JA, Keyes MJ, Mitchell GF: Associations of plasma
natriuretic peptide, adrenomedullin, and homocysteine levels with alterations in arterial
stiffness: the Framingham Heart Study. Circulation 2007; 115(24):3079-3085
PM:17533184.
Levy D, Larson MG, Benjamin EJ, Newton-Cheh C, Wang TJ, Hwang SJ, Vasan RS,
Mitchell GF: Framingham Heart Study 100K Project: genome-wide associations for
blood pressure and arterial stiffness. BMC Med Genet 2007; 8 Suppl 1:S3
PM:17903302.

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Lievers KJ, Kluijtmans LA, Blom HJ, Wilson PW, Selhub J, Ordovas JM: Association of a
31 bp VNTR in the CBS gene with postload homocysteine concentrations in the
Framingham Offspring Study. Eur J Hum Genet 2006; 14(10):1125-1129 PM:16791140.
Lin JP, O'Donnell CJ, Jin L, Fox C, Yang Q, Cupples LA: Evidence for linkage of red
blood cell size and count: genome-wide scans in the Framingham Heart Study. Am J
Hematol 2007; 82(7):605-610 PM:17211848.
Lunetta KL, D'Agostino RB, Sr., Karasik D, Benjamin EJ, Guo CY, Govindaraju R, Kiel
DP, Kelly-Hayes M, Massaro JM, Pencina MJ, Seshadri S, Murabito JM: Genetic
correlates of longevity and selected age-related phenotypes: a genome-wide association
study in the Framingham Study. BMC Med Genet 2007; 8 Suppl 1:S13 PM:17903295.
Lyon HN, Emilsson V, Hinney A, Heid IM, Lasky-Su J, Zhu X, Thorleifsson G,
Gunnarsdottir S, Walters GB, Thorsteinsdottir U, Kong A, Gulcher J, Nguyen TT,
Scherag A, Pfeufer A, Meitinger T, Bronner G, Rief W, Soto-Quiros ME, Avila L,
Klanderman B, Raby BA, Silverman EK, Weiss ST, Laird N, Ding X, Groop L, Tuomi T,
Isomaa B, Bengtsson K, Butler JL, Cooper RS, Fox CS, O'Donnell CJ, Vollmert C,
Celedon JC, Wichmann HE, Hebebrand J, Stefansson K, Lange C, Hirschhorn JN: The
association of a SNP upstream of INSIG2 with body mass index is reproduced in several
but not all cohorts. PLoS Genet 2007; 3(4):e61 PM:17465681.
Maia AL, Dupuis J, Manning A, Liu C, Meigs JB, Cupples LA, Larsen PR, Fox CS: The
type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the
Framingham Heart Study. Thyroid 2007; 17(3):199-202 PM:17381351.
Marrugat J, Subirana I, Comin E, Cabezas C, Vila J, Elosua R, Nam BH, Ramos R, Sala
J, Solanas P, Cordon F, Gene-Badia J, D'Agostino RB: Validity of an adaptation of the
Framingham cardiovascular risk function: the VERIFICA Study. J Epidemiol Community
Health 2007; 61(1):40-47 PM:17183014.
Maurovich-Horvat P, Massaro J, Fox CS, Moselewski F, O'Donnell CJ, Hoffmann U:
Comparison of anthropometric, area- and volume-based assessment of abdominal
subcutaneous and visceral adipose tissue volumes using multi-detector computed
tomography. Int J Obes (Lond) 2007; 31(3):500-506 PM:16953256.
Meigs JB, Larson MG, Fox CS, Keaney JF, Jr., Vasan RS, Benjamin EJ: Association of
oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham
Offspring Study. Diabetes Care 2007; 30(10):2529-2535 PM:17586736.
Meigs JB, Rutter MK, Sullivan LM, Fox CS, D'Agostino RB, Sr., Wilson PW: Impact of
insulin resistance on risk of type 2 diabetes and cardiovascular disease in people with
metabolic syndrome. Diabetes Care 2007; 30(5):1219-1225 PM:17259468.
Meigs JB, Manning AK, Fox CS, Florez JC, Liu C, Cupples LA, Dupuis J: Genome-wide
association with diabetes-related traits in the Framingham Heart Study. BMC Med Genet
2007; 8 Suppl 1:S16 PM:17903298.
Mitchell GF, Guo CY, Kathiresan S, Vasan RS, Larson MG, Vita JA, Keyes MJ, Vyas M,
Newton-Cheh C, Musone SL, Camargo AL, Drake JA, Levy D, O'Donnell CJ, Hirschhorn
JN, Benjamin EJ: Vascular stiffness and genetic variation at the endothelial nitric oxide

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synthase locus: the Framingham Heart study. Hypertension 2007; 49(6):1285-1290
PM:17404185.
Mitchell GF, Vasan RS, Keyes MJ, Parise H, Wang TJ, Larson MG, D'Agostino RB, Sr.,
Kannel WB, Levy D, Benjamin EJ: Pulse pressure and risk of new-onset atrial fibrillation.
JAMA 2007; 297(7):709-715 PM:17312290.
Mitchell GF, Guo CY, Benjamin EJ, Larson MG, Keyes MJ, Vita JA, Vasan RS, Levy D:
Cross-sectional correlates of increased aortic stiffness in the community: the
Framingham Heart Study. Circulation 2007; 115(20):2628-2636 PM:17485578.
Murabito JM, Guo CY, Fox CS, D'Agostino RB: Heritability of the ankle-brachial index:
the Framingham Offspring study. Am J Epidemiol 2006; 164(10):963-968 PM:16928729.
Murabito JM, Rosenberg CL, Finger D, Kreger BE, Levy D, Splansky GL, Antman K,
Hwang SJ: A genome-wide association study of breast and prostate cancer in the
NHLBI's Framingham Heart Study. BMC Med Genet 2007; 8 Suppl 1:S6 PM:17903305.
Newton-Cheh C, Guo CY, Larson MG, Musone SL, Surti A, Camargo AL, Drake JA,
Benjamin EJ, Levy D, D'Agostino RB, Sr., Hirschhorn JN, O'Donnell CJ: Common
genetic variation in KCNH2 is associated with QT interval duration: the Framingham
Heart Study. Circulation 2007; 116(10):1128-1136 PM:17709632.
Newton-Cheh C, Guo CY, Gona P, Larson MG, Benjamin EJ, Wang TJ, Kathiresan S,
O'Donnell CJ, Musone SL, Camargo AL, Drake JA, Levy D, Hirschhorn JN, Vasan RS:
Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood
pressure in a community sample. Hypertension 2007; 49(4):846-856 PM:17296870.
Newton-Cheh C, Guo CY, Wang TJ, O'Donnell CJ, Levy D, Larson MG: Genome-wide
association study of electrocardiographic and heart rate variability traits: the
Framingham Heart Study. BMC Med Genet 2007; 8 Suppl 1:S7 PM:17903306.
O'Donnell CJ, Shea MK, Price PA, Gagnon DR, Wilson PW, Larson MG, Kiel DP,
Hoffmann U, Ferencik M, Clouse ME, Williamson MK, Cupples LA, wson-Hughes B,
Booth SL: Matrix Gla protein is associated with risk factors for atherosclerosis but not
with coronary artery calcification. Arterioscler Thromb Vasc Biol 2006; 26(12):2769-2774
PM:16973975.
O'Donnell CJ, Cupples LA, D'Agostino RB, Fox CS, Hoffmann U, Hwang SJ, Ingellson
E, Liu C, Murabito JM, Polak JF, Wolf PA, Demissie S: Genome-wide association study
for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham
Heart Study. BMC Med Genet 2007; 8 Suppl 1:S4 PM:17903303.
Parikh NI, Hwang SJ, Larson MG, Cupples LA, Fox CS, Manders ES, Murabito JM,
Massaro JM, Hoffmann U, O'Donnell CJ: Parental occurrence of premature
cardiovascular disease predicts increased coronary artery and abdominal aortic
calcification in the Framingham Offspring and Third Generation cohorts. Circulation
2007; 116(13):1473-1481 PM:17785619.

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Parikh NI, Pencina MJ, Wang TJ, Lanier KJ, Fox CS, D'Agostino RB, Vasan RS:
Increasing trends in incidence of overweight and obesity over 5 decades. Am J Med
2007; 120(3):242-250 PM:17349447.
Patwardhan AA, Larson MG, Levy D, Benjamin EJ, Leip EP, Keyes MJ, Wang TJ,
Gottlieb DJ, Vasan RS: Obstructive sleep apnea and plasma natriuretic peptide levels in
a community-based sample. Sleep 2006; 29(10):1301-1306 PM:17068983.
Pencina MJ, D'Agostino RB, Beiser AS, Cobain MR, Vasan RS: Estimating lifetime risk
of developing high serum total cholesterol: adjustment for baseline prevalence and
single-occasion measurements. Am J Epidemiol 2007; 165(4):464-472 PM:17116649.
Pencina MJ, Larson MG, D'Agostino RB: Choice of time scale and its effect on
significance of predictors in longitudinal studies. Stat Med 2007; 26(6):1343-1359
PM:16955538.
Peter I, Huggins GS, Shearman AM, Pollak A, Schmid CH, Cupples LA, Demissie S,
Patten RD, Karas RH, Housman DE, Mendelsohn ME, Vasan RS, Benjamin EJ: Agerelated changes in echocardiographic measurements: association with variation in the
estrogen receptor-alpha gene. Hypertension 2007; 49(5):1000-1006 PM:17372038.
Pou KM, Massaro JM, Hoffmann U, Vasan RS, Maurovich-Horvat P, Larson MG,
Keaney JF, Jr., Meigs JB, Lipinska I, Kathiresan S, Murabito JM, O'Donnell CJ,
Benjamin EJ, Fox CS: Visceral and subcutaneous adipose tissue volumes are crosssectionally related to markers of inflammation and oxidative stress: the Framingham
Heart Study. Circulation 2007; 116(11):1234-1241 PM:17709633.
Quan SF, O'connor GT, Quan JS, Redline S, Resnick HE, Shahar E, Siscovick D,
Sherrill DL: Association of physical activity with sleep-disordered breathing. Sleep Breath
2007; 11(3):149-157 PM:17221274.
Rumawas ME, McKeown NM, Rogers G, Meigs JB, Wilson PW, Jacques PF:
Magnesium intake is related to improved insulin homeostasis in the Framingham
offspring cohort. J Am Coll Nutr 2006; 25(6):486-492 PM:17229895.
Salaycik KJ, Kelly-Hayes M, Beiser A, Nguyen AH, Brady SM, Kase CS, Wolf PA:
Depressive symptoms and risk of stroke: the Framingham Study. Stroke 2007; 38(1):1621 PM:17138952.
Samelson EJ, Cupples LA, Broe KE, Hannan MT, O'Donnell CJ, Kiel DP: Vascular
calcification in middle age and long-term risk of hip fracture: the Framingham Study. J
Bone Miner Res 2007; 22(9):1449-1454 PM:17542685.
Schaefer EJ, Bongard V, Beiser AS, Lamon-Fava S, Robins SJ, Au R, Tucker KL, Kyle
DJ, Wilson PW, Wolf PA: Plasma phosphatidylcholine docosahexaenoic acid content
and risk of dementia and Alzheimer disease: the Framingham Heart Study. Arch Neurol
2006; 63(11):1545-1550 PM:17101822.
Scranton RE, Bozeman SR, Burton TM, Hoaglin DC, Sirko S, Hollenbeak CS, Wilson
PW: Simple demographic model to predict multiple cardiometabolic risk factors in two
well-known observational cohorts. Value Health 2007; 10(s1):S37-S44 PM:17229129.

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